What is the role of serine and histidine in the mechanistic step shown in Figure 1? Propose a role for the catalytic triad glutamate residue.
Requirements: short answer From Poison to Medicine Mechanisms and an Antidote Acetylcholinesterase catalyzes the hydrolysis of acetylcholine to acetic acid and choline. This is a two-stage process involving hydrolysis (Figure 1). Figure 1: Acetylcholinesterase overall reaction The first step forms the intermediate that is shown in the PDB ID: 2ACE crystal structure and is diagrammed […]