In orotic aciduria, the activities of two components of a large enzyme complex are deficient: both orotate phosphoribosyl transferase (synthesizes nucleotides) and orotod
In orotic aciduria, the activities of two components of a large enzyme complex are deficient: both orotate phosphoribosyl transferase (synthesizes nucleotides) and orotodylic acid decarboxylase (converts OMP toUMP) are inactive. This leads to orotic acid build up and DNA and RNA will not be synthesized. Pyrimidines as uridine (uridine-riboside are used and administered to treat […]