A prospective cohort study is investigating the relationship between maternal plasma homocysteine during pregnancy and risk for low birth weight. The study uses an inexpensive laboratory mea
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Get it written →A prospective cohort study is investigating the relationship between maternal plasma homocysteine during pregnancy and risk for low birth weight. The study uses an inexpensive laboratory measure of homocysteine taken at the 3 month time point of
pregnancy. The gold standard is an expensive method taken 3 times during the pregnancy. For a subset of the study subjects they are also able to measure with the gold standard measure. The plot below represents the pattern of measurement error between the study exposure method and the gold standard.
a) Describe the pattern of measurement error observed
b) How does this relative risk estimate compare (higher, lower, or the same) to what would have been observed if the study had used the gold standard measure.
c) How would the measurement error impact the proportion of women classified as having hyperhomocysteinemia (a homocysteine level > 15 μmol/L) in this study
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