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November 29, 2022

How to calculate the concentration of the drug after giving a combination of IV bolus loading dose and maintenance infusion dose .

How to calculate the concentration of the drug after giving a combination of IV bolus loading dose and maintenance infusion dose . At time = 6 hr Cp total = CPIv + CPinfusion 20- Cp total = (Cp e-Kt) . (RAVd K)(1- e -Kt) Combined IV Bolus and Infusion Dose (bolus)= 353 mg; R =60 mg/hr. k = 0.17 hr(-1); Va= 25L . At time = 27 (drug reach steady state) 15- Cp total = CPIv + CPinfusion Cp total = (Cp e-Kt) + CPss Cp (mg/L) 10- Concentration due to infusion Cp total = (Cp e-Kt) . (RAVd K) . At time = 30 (assume infusion was Concentration due to loading dose stopped at 27hr) Cp total = CPIv + CPinfusion 12 18 24 Cp total = (Cp e-Kt) . (Cpole -Ki) Time (hour) Cpol is the concentration of the drug whet, infusion has been stopped

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