Plasma: What is the primary component of plasma?
This is the questions
Part 3. Plasma
What is the primary component of plasma? ___________________
Fill in the chart regarding the plasma proteins:
Plasma Proteins % Total Plasma Proteins Production Site Functions
Albumin
Globulins
Fibrinogens
Part 4: Hematopoiesis
What is hematopoiesis? ___________________________________________________________________________
Where does hematopoiesis occur in healthy adults? _____________________________________________________
Fill in the chart regarding specialized hematopoietic stem cells:
Specialized Hematopoietic Stem Cell Cells That Arise from this Stem Cell
Fill in the chart regarding hematopoietic growth factors:
Hematopoietic Growth Factor What Does it Trigger?
Part 5: Erythrocyte Structure
What is the scientific term for a red blood cell? ___________________________
What is the primary function of RBCs? _____________________________________________________________
What is the name for the immature circulating RBC? __________________________________________________
What is the shape of red blood cells? ___________________________________
What causes the RBC to be shaped this way? _________________________________________________________ _____________________________________________________________________________________________
What is the purpose of this shape? _________________________________________________________________ _____________________________________________________________________________________________
Part 6: Hemoglobin
What is the function of hemoglobin? _______________________________________________________________
What are the four folded protein chains in the hemoglobin molecule called? ________________________
What is a heme group? _________________________________________________________________________
How many heme groups are found on each hemoglobin molecule? ____________
How many oxygen molecules can each molecule of hemoglobin carry? ___________
What is the term for hemoglobin that has picked up oxygen? _________________________________
What is the term for hemoglobin that has released oxygen? __________________________________
What is meant by percent saturation of blood? _______________________________________________________
What is the clinical importance of percent saturation? _________________________________________________
Which device is used to measure percent oxygen saturation? ___________________________________________
What are normal pulse oximeter values? ___________________
What term is used to describe percent oxygen saturation that is below normal? ______________________________
How do the kidneys help to regulate hemoglobin production? _____________________________________
___________________________________________________________________________________________
___________________________________________________________________________________________
Part 7: Erythrocyte Life Cycle
Where are RBCs produced? ___________________________
Which hormone stimulates the production of RBCs? ________________________
How long do RBCs circulate? _____________________
Which organs are responsible for breaking down erythrocytes? _______________________________________
Define anemia: ____________________________________________________________________________
Why is anemia a problem? ___________________________________________________________________
Define polycythemia: _______________________________________________________________________
Why is polycythemia a problem? ______________________________________________________________
Part 8: Leukocytes
What is the general function of leukocytes? _________________________________________________________
List some ways that leukocytes are different from erythrocytes:
________________________________________________________________________________________
________________________________________________________________________________________
________________________________________________________________________________________
What is the difference between the granulocytes and agranulocytes? _____________________________________
___________________________________________________________________________________________
___________________________________________________________________________________________
List the:
Granulocytes Agranulocytes
Which leukocytes are most numerous? ___________________________
Match the following leukocytes with the ALL OF the descriptions that match them best:
__________ neutrophils A. present in parasitic infections H. deep purple (blue) staining granulezs
__________ eosinophils B. Viral infections and cancer I. contains lysozymes
__________ basophils C. red-staining granules J. horseshoe-shaped nuclei
__________ monocytes D. present in bacterial infections K. may be B or T cells
__________ lymphocytes E. contain histamine molecules L. large, round nuclei
F. present in viral infections M. contain anti-histamine molecules
G. turn into macrophages N. present in allergic reactions
Part 9: Platelets
From which cell do platelets arise? ____________________
Briefly describe platelet structure: ____________________________________________________________________
What is the primary function of platelets? __________________
Access the links to the Histology Guide Slide Box in Lesson 1, Part 9 and label the following cells::
Erythrocyte, platelet, neutrophil, eosinophil, basophil, lymphocyte, monocyte
___________________________ ____________________________ ____________________________
___________________________ ____________________________ ____________________________
____________________________
Lesson 2: Blood Physiology
Part 1. Hemostasis
Define hemostasis? ___________________________________________________________________________
List and briefly describe the three steps in hemostasis
Step Description Purpose
Which chemicals trigger vascular spasm? ____________________________
What, specifically, is the final product of the clotting cascade? ____________________________
Why is coagulation referred to as a “cascade”? ________________________________________________________
_____________________________________________________________________________________________
How many clotting factors are there? ________________________
Where are most clotting factors secreted from? _________________________________________________________
What is the process by which a clot is dissolved? _______________________________
Part 2. Blood Typing
Antigens on a red blood cell are also called _________________________.
Antibodies circulating in plasma that are against the antigens on a red blood cell are ________________________.
Fill in the chart regarding blood types:
Blood Type Agglutinogens on RBCs Agglutinins circulating in plasma
A
B
AB
O
If the Rh antigen is present on the surface of a blood cell, what is the Rh designation? _______
If the Rh antigen is absent from the surface of a blood cell, what is the Rh designation? _______
Part 3. Genetics of Blood Typing
What are all of the possible genotypes for each blood type?
Phenotype (Blood Types) Possible Genotypes
A
B
AB
O
Rh+
Rh-
Fill in the Punnett Square for a cross between a type AB mother and a type O father (Mother’s alleles in top column, father’s alleles along left side):
Fill in the Punnett squares for a cross between an Rh+ mother and an Rh- father (all possible combinations)
Blood Typing Activity: Who is the Father of This Child?
Use the information in the blood typing activity section to fill in the following chart:
Anti-A serum (clump or no clump) Anti-B serum (clump or no clump) Anti-Rh serum (clump or no clump)
Blood Type
(Phenotype)
Mom
Baby
Dad #1
Dad #2
Based on the above table, use Punnett squares to determine the possible father of the baby. Make sure you indicate who the possible father is as well as why he is and why the other man is not.
Part 4: Blood Transfusions
People with which blood type are considered to be universal donors? _________
Why? ____________________________________________________________________________________________
____________________________________________________________________________________________
People with which blood type are considered to be universal recipients? _________
Why? ____________________________________________________________________________________________
____________________________________________________________________________________________
Part 5: Hemolytic Disease of the Newborn
When does HDN occur? ______________________________________________________________________________
__________________________________________________________________________________________________
Why is HDN dangerous? ______________________________________________________________________________
__________________________________________________________________________________________________
What can be done to prevent HDN? ______________________________________________________________________
__________________________________________________________________________________________________
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