F1 (AxB) mice are infected with a virus, and 7 days later their spleen contain CTL that lyse virally infected A and B targets.
F1 (AxB) mice are infected with a virus, and 7 days later their spleen contain CTL that lyse virally infected A and B targets. The harvested spleen are then transferred to irradiated A strain mice that are virally infected, and 5 days later the spleen is harvested. This spleen contains CTL that readily lyse virally infected A targets but lyse very poorly virally infected B targets. This experiment suggests there are separate CTL recognizing A and B infected cells. Why is it essential to the design of this experiment that the recipient A strain mouse is irradiated?
BMIS 321_821 2022 Section Il.doc [Compatibility Mode] – Word Stephen Harrison X File Home Insert Design Layout References Mailings Review View Help Tell me what you want to do individual CTL can only recognize target cells from one parent or from both. The following experiment shows that individual CTL can only recognize virally infected cells of one parent. Consider a virally infected A/B mouse that has CTL able to lyse v.A and v.B targets. We ought to be able, if separate CTL recognize these two targets, to expand up these two populations separately by exposing them to the appropriate antigen. Thus the A/B CTL, when stimulated by only v.A cells, would now be expected to preferentially lyse V.A targets if separate CTL exist. The results summarized in Figure 5 show this to be the case. In summary, individual virus-specific CTL recognize something that depends on both the virus and one class I antigen, either K or D. F : A+B Lekal irradiation CTL virus injectal virus Lymphocytes after "irradiation A strain mouse lyse v. A ) targets Y. BJ few days later, CTL lyse v.A but not v. B FIGURE 5 (PAB) Page 57 of 75 1 of 23584 words [x English (United States) a Accessibility: Unavailable – + 124% 11:16 PM Type here to search O O W – 90C A DI ENG 2022-11-02
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