Positive breast cancer
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Get it written →Below is a figure from Linde et al (2018)Nature Communication 9:21.In the paper, the authors used a mouse model of HER2-positive breast cancer and showed that macrophages play a critical role in metastasis. Please answer the following:
a. In the schematic diagramin the Figure panel a, the authorsinjected mice with antibody against CSF1R (colony stimulating factor1 receptor). What is the point of this antibody treatment?
b. In the Figurepanel d, the authors used qPCR (quantitative PCR) to measureE-cad expression. What is a significance of measuring E-cad?
c. In the panelsd and g, what do the resultsshow?
d. In the panelh, eCCCs (earlycirculating cancer cells)were measured in the peripheral blood. What does the result show?
e What conclusion can you draw from this figure relatedto macrophages and cancer metastasis (hint: anti-CSF1R treatment cause and effect)?
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