Provide a subsequent commentary outlining the key observations, concentrating on the certainty of the individual trial results and the indirect comparison in respect to risk difference.
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Get it written →Provide a subsequent commentary outlining the key observations, concentrating on the certainty of the individual trial results and the indirect comparison in respect to risk difference.
PEM + LEN (N=352) Pazopanib (N=554) Odds Ratio
(95% CI) Relative Risk
(95% CI) Risk Difference
(95% CI)
Any Event 351 (99.7) 538 (97.1) 10.44 (1.38, 79.07) 1.03 (1.01, 1.04) 2.6 (1.1, 4.1)
Diarrhoea 216 (61.4) 321 (57.9) 1.15 (0.88, 1.51) 1.06 (0.95, 1.18) 3.4 (-3.1, 10.0)
Fatigue 141 (40.1) 273 (49.3) 0.69 (0.52, 0.90) 0.81 (0.70, 0.95) -9.2 (-15.8, -2.6)
Hypertension 195 (55.4) 240 (43.3) 1.63 (1.24, 2.13) 1.28 (1.12, 1.46) 12.1 (5.4, 18.7)
Nausea 126 (35.8) 223 (40.3) 0.83 (0.63, 1.09) 0.89 (0.75, 1.06) -4.5 (-10.9, 2.0)
Stomatitis 122 (34.7) 72 (13.0) 3.55 (2.55, 4.94) 2.67 (2.06, 3.45) 21.7 (16.0, 27.4)
Proteinuria 104 (29.5) 89 (16.1) 2.19 (1.59, 3.02) 1.84 (1.43, 2.36) 13.5 (7.8, 19.1)
Vomiting 92 (26.1) 133 (24.0) 1.12 (0.82, 1.52) 1.09 (0.87, 1.37) 2.1 (-3.7, 7.9)
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