Integrative Analysis of the Biological Bases of Human Behavior
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Slide 1 – Title Slide
Header: Integrative Analysis of the Biological Bases of Human Behavior
Slide 2 – Introduction
Overview of taking a biopsychosocial approach to understand the complex factors influencing human behavior
Focus on contribution of biological systems and processes
Analysis examines psychobiological factors, focusing on addiction as a case study
Slide 3 – What is Psychobiology?
Interdisciplinary field integrating biological and psychological perspectives.
Examines how genetics, evolution, neurochemistry, neuroanatomy, physiology shape behavior
(Cacioppo & Freberg, 2016)
Slide 4 – Key Areas of Psychobiology
Genetics – gene variants linked to behavioral traits
Evolution – adaptive behaviors encoded genetically
Neurotransmitters – regulate cognition, mood, motivation
Neuroanatomy – specialized brain regions govern functions
Neuroendocrinology – hormones coordinate physiology & behavior
Neuroplasticity – neural connections change with experience
Slide 5 – Neurotransmitters & Behavior
Different neurotransmitters modulate diverse functions
Imbalances linked to psychological disorders
Examples: Dopamine, serotonin, acetylcholine, GABA, glutamate
(Jasinska et al., 2014)
Slide 6 – Brain Disorders & Behavioral Impact
Stroke, dementia, epilepsy, Parkinson’s, schizophrenia
Damage to specialized regions impairs associated functions
(American Psychiatric Association, 2013)
Slide 7 – Biological Factors in Addiction
Genetic vulnerabilities make some more addiction prone
Chronic drug use alters reward/motivation pathways
Enhanced craving neurocircuitry drives relapse
Executive function deficits perpetuate addiction cycle
(American Psychiatric Association, 2013)
Slide 8 – Genetic Predispositions
Twin studies show addiction is 40-60% heritable (Ducci & Goldman, 2012).
Specific gene variants linked to altered signaling & metabolism (Walters, 2002).
Heightened impulsivity, reward sensitivity in some
Slide 9 – Neural Adaptations in Addiction
Drugs overstimulate dopamine reward pathways
With repeated use, signaling dampens, tolerance builds
Motivation shifts from natural to drug rewards
(Volkow et al., 2016)
Slide 10 – Conclusion
Biology and psychology shape human behavior interactively
Psychobiology framework enables better understanding and treatments
Integrative approach key to addressing behavioral disorders
Slide 11- References
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.).
Cacioppo, J. T., & Freberg, L. A. (2016). Discovering psychology: The science of mind (3rd ed.). Cengage Learning.
Ducci, F., & Goldman, D. (2012). The genetic basis of addictive disorders. The Psychiatric Clinics of North America, 35(2), 495-519.
Jasinska, A. J., Stein, E. A., Kaiser, J., Naumer, M. J., & Yalachkov, Y. (2014). Factors modulating neural reactivity to drug cues in addiction: A survey of human neuroimaging studies. Neuroscience & Biobehavioral Reviews, 38, 1-16.
Volkow, N. D., Koob, G. F., & McLellan, A. T. (2016). Neurobiology advances from the brain disease model of addiction. New England Journal of Medicine, 374(4), 363-371.
Walters, G. D. (2002). Behavior genetic research on drug abuse and dependence: A review and update. The American Journal on Addictions, 11(1), 26-39.
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