Identify any evidence-based support for the claims made in the literature.
Begin by selecting a topic pertaining to genes and gene-environment interaction from one of the following resources:
Refer to chapters 4 and 5 of your text, unit II
Select a topic from the list below
Look for ideas in the WCU Library databases
Conduct a literature search of recent journal articles (peer reviewed) within the last three years that pertain to your topic. You must select three articles for this assignment.
Synthesize the knowledge gained from the chapter readings and your literature research into a comprehensive understanding of the topic.
Identify any evidence-based support for the claims made in the literature.
Draw and summarize your own unique conclusions based on a comprehensive understanding of the topic and your research.
Sample Topics
Down syndrome
Fragile X syndrome
Turner syndrome
Triple X syndrome
Klinefelter syndrome
Consider the familial tendencies and contributing environmental factors (nature/nurture debate) in one of the following diseases: coronary artery disease (CAD), hypercholesterolemia, hypertension, colorectal cancer, diabetes, breast cancer, and obesity
Complex multifactorial diseases such as Alzheimer disease, alcoholism, schizophrenia, and bipolar disorder
Twin studies that helped determine that type 1 diabetes is multifactorial
The genetic inheritance of alcoholism
Your paper should be 4–5 pages in length (excluding cover page and reference page).
Inlcude at least three scholarly sources in your paper in addition to citing the course etext.
Use APA format to style your paper and to cite your sources. Your source(s) should be integrated into the paragraphs. Use internal citations pointing to evidence in the literature and supporting your ideas. You will need to include a reference page listing those sources.
Be sure to allow time for proofreading and editing. Budget your time to take advantage of Tutor.com services.
Review the rubric for more information on how your assignment will be graded.
NURS530 Advanced Physiology and Pathophysiology
Week 2 Assignment
Case Study
The purpose of the case study is to have you expand upon the pathophysiological disease process by searching for evidence-based practice treatment and advanced practice nursing role implications related to the disease.
Case Study Topic:
Select a type of cancer (breast, lung, prostate, or colon cancer, melanoma, or any type of leukemia) and discuss the relationship of the disease process to the immune system.
Identify current evidence-based treatment modalities for the selected cancer and discuss how the treatment impacts the disease process.
Conduct an evidence-based literature search to identify the most recent standards of care/treatment modalities from peer-reviewed articles and professional association guidelines (www.guideline.gov). These articles and guidelines can be referenced, but not directly copied into the clinical case presentation. Cite a minimum of three resources.
Include the following in your clinical case presentation:
A discussion of the pathophysiology of the disease, including signs and symptoms.
An explanation of diagnostic testing and rationales for each.
A review of different evidence-based treatment modalities for the disorder obtained from guideline.gov or a professional organization.
Next, address the following questions:
How does the information in this case inform the practice of a master’s prepared nurse?
How should the master’s prepared nurse use this information to design a patient education session for someone with this condition?
What was the most important information presented in this case?
What was the most confusing or challenging information presented in this case?
Discuss a patient safety issue that can be addressed for a patient with the condition presented in this case.
The use of medical terminology and appropriate graduate level writing is expected.
Your paper should be 3–4 pages (excluding cover page and reference page).
Your resources must include research articles as well as reference to non-research evidence-based guidelines.
Use APA format to style your paper and to cite your sources. Your source(s) should be integrated into the paragraphs. Use internal citations pointing to evidence in the literature and supporting your ideas. You will need to include a reference page listing those sources. Cite a minimum of three resources.
Review the rubric for more information on how your assignment will be graded.
Use APA format to style your paper and to cite your sources. Your source(s) should be integrated into the paragraphs. Use internal citations pointing to evidence in the literature and supporting your ideas. You will need to include a reference page listing those sources.
Review the rubric for more information on how your assignment will be graded.
NURS530 Advanced Physiology and Pathophysiology
Week 3 Assignment
Case Study
The purpose of the case study is to have you expand on the pathophysiological disease process by searching for evidence-based practice treatment and advanced practice nursing role implications related to the disease.
Case Study Topic:
Select either a type of pain syndrome or a neurologic disease process (headache, CVA, acute bacterial meningitis, Alzheimer’s, anxiety, depression, chronic pain syndrome) and discuss the pathophysiologic process involved.?
Identify current evidence-based treatment modalities for the selected syndrome or disease and discuss how the treatment impacts the disease process.
Conduct an evidence-based literature search to identify the most recent standards of care/treatment modalities from peer-reviewed articles and professional association guidelines (www.guideline.gov). These articles and guidelines can be referenced, but not directly copied into the clinical case presentation. Cite a minimum of three resources.
Include the following in your clinical case presentation:
A discussion of the pathophysiology of the disease, including signs and symptoms.
An explanation of diagnostic testing and rationales for each.
A review of different evidence-based treatment modalities for the disorder obtained from guideline.gov or a professional organization.
Next, address the following questions:
How does the information in this case inform the practice of a master’s prepared nurse?
How should the master’s prepared nurse use this information to design a patient education session for someone with this condition?
What was the most important information presented in this case?
What was the most confusing or challenging information presented in this case?
Discuss a patient safety issue that can be addressed for a patient with the condition presented in this case.
The use of medical terminology and appropriate graduate level writing is expected.
Your paper should be 3–4 pages (excluding cover page and reference page).
Your resources must include research articles as well as reference to non-research evidence-based guidelines.
Use APA format to style your paper and to cite your sources. Your source(s) should be integrated into the paragraphs. Use internal citations pointing to evidence in the literature and supporting your ideas. You will need to include a reference page listing those sources. Cite a minimum of three resources.
NURS530 Advanced Physiology and Pathophysiology
Week 4 Assignment
Video Presentation
The purpose of this assignment is to demonstrate understanding through teaching and explanation. Begin by choosing one of the topics below, or propose a topic of your own interest from the assigned readings subject to instructor approval. Post your choice to the discussion board thread “Video Presentation Topics” as soon as you make your choice. You may not select a topic that has already been chosen by a classmate. The sooner you choose, the more options you will have.
For this assignment, you will produce a 4–7 minute audio–video presentation on your chosen topic.
Record, Upload, and Submit
The Kaltura Desktop Recording tool is available for free to WCU students to assist with recording video assignments. Another software or tool may be used to record your assignment. Completed videos are required to be uploaded to your Kaltura My Media area before they can be submitted in the Blackboard assignment area via Mashups Tool > Kaltura Media.
Kaltura Mashups Tool
In your presentation, include the following:
Include at least one type of visual aid in your presentation such as PowerPoint slides, diagrams, white board use, etc.
You are expected to explain the processes or concepts in your own words using references to support your explanations. Include a reference list at the end and cite references verbally or with on screen citations.
Use appropriate master’s level terminology.
Include all necessary physiology and/or pathophysiology in your explanation.
Use detailed explanations to teach or explain. Your classmates and professional colleagues are your audience .
Reference a minimum of two sources; you may cite your etext as a source. Use APA format to style your visual aids and cite your sources. Include a reference page in your video.
Your presentation must include both audio and visual components and be professional in nature.
Possible topics:
Explain endocrine feedback in terms of short, long, and ultra-short feedback loops
Explain the two general effects hormones have on cells: direct effects, or obvious changes in cell function, and permissive effects, or less obvious changes that facilitate cell function
Explain methods used to measure the levels of hormones in the plasma
Describe the causative factor and manifestations for the hypersecretion of prolactin
Discuss the causes of hyperpituitarism and hypopituitarism with consideration of the populations at highest risk for the development of the disorders
Characterize the manifestations of hypothyroidism and hyperthyroidism
Explain the process of thermoregulation
Explain the process of glucose regulation
Discuss the similarities of breast cancer invasion and normal mammary gland branching
Explain the role of myoepithelial cells in invasive breast cancer
Explain the causes of delayed or incomplete puberty
Relate luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels to the stages of follicle development and to progesterone and estrogen production
Describe the functions of the female breast, and discuss the cyclic, hormone-mediated changes in the breast tissue during the reproductive years and with pregnancy
Describe the conditions present and pathophysiology of polycystic ovarian syndrome (PCOS)
Describe the clinical presentation and pathophysiology of gonorrhea
Describe the clinical presentation and pathophysiology of hepatitis B
Describe the clinical presentation and pathophysiology of acquired immunodeficiency syndrome (AIDS)
Propose a topic of your own interest from the assigned readings; however, it must be submitted to your instructor for approval
You will post your finished presentation here for grading, and you will post a copy to the discussion board thread “Final Video Presentations” to be shared and reviewed with your classmates.
NURS530 Advanced Physiology and Pathophysiology
Week 5 Assignment
Case Study
The purpose of the case study is to have you expand on the pathophysiological disease process by searching for evidence-based practice treatment and advanced practice nursing role implications related to the disease.
Case Study Topic:
Select an alteration of the hematologic system (iron deficiency, megaloblastic, hemolytic, or anemia of chronic disease, thalassemia, sickle cell disease, or a bleeding disorder) and explain the expected alterations in laboratory values seen in patients with this condition.?
Analyze current evidence-based treatment modalities specific to the aging population and include evidence-based treatment guidelines for the selected processes.
Conduct an evidence-based literature search to identify the most recent standards of care/treatment modalities from peer-reviewed articles and professional association guidelines (www.guideline.gov). These articles and guidelines can be referenced, but not directly copied into the clinical case presentation. Cite a minimum of three resources.
Include the following in your clinical case presentation:
A discussion of the pathophysiology of the disease, including signs and symptoms.
An explanation of diagnostic testing and rationales for each.
A review of different evidence-based treatment modalities for the disorder obtained from guideline.gov or a professional organization.
Next, address the following questions:
How does the information in this case inform the practice of a master’s prepared nurse?
How should the master’s prepared nurse use this information to design a patient education session for someone with this condition?
What was the most important information presented in this case?
What was the most confusing or challenging information presented in this case?
Discuss a patient safety issue that can be addressed for a patient with the condition presented in this case.
The use of medical terminology and appropriate graduate level writing is expected.
Your paper should be 3–4 pages (excluding cover page and reference page).
Your resources must include research articles as well as reference to non-research evidence-based guidelines.
Use APA format to style your paper and to cite your sources. Your source(s) should be integrated into the paragraphs. Use internal citations pointing to evidence in the literature and supporting your ideas. You will need to include a reference page listing those sources. Cite a minimum of three resources.
NURS530 Advanced Physiology and Pathophysiology
Week 6 Assignment
Case Study
The purpose of the case study is to have you expand upon the pathophysiological disease process by searching for evidence-based practice treatment and advanced practice nursing role implications related to the disease.
Case Study Topic:
Select a cardiovascular or respiratory disease process (hypertension, heart failure, dyslipidemia, ischemic heart disease, asthma, COPD, or pneumonia) and discuss how the patient’s lifestyle and environment impacts the disease process.
Identify evidence-based pharmacologic and non-pharmacologic interventions appropriate for the selected disease process. ?
Include evidence-based treatment guidelines for the selected processes.
Analyze current evidence-based treatment modalities specific to the aging population and include evidence-based treatment guidelines for the selected processes.
Conduct an evidence-based literature search to identify the most recent standards of care/treatment modalities from peer reviewed articles and professional association guidelines (www.guideline.gov). These articles and guidelines can be referenced, but not directly copied into the clinical case presentation. Cite a minimum of three resources.
Include the following in your clinical case presentation:
A discussion of the pathophysiology of the disease, including signs and symptoms.
An explanation of diagnostic testing and rationales for each.
A review of different evidence-based treatment modalities for the disorder obtained from guideline.gov or a professional organization.
Next, address the following questions:
How does the information in this case inform the practice of a master’s prepared nurse?
How should the master’s prepared nurse use this information to design a patient education session for someone with this condition?
What was the most important information presented in this case?
What was the most confusing or challenging information presented in this case?
Discuss a patient safety issue that can be addressed for a patient with the condition presented in this case.
The use of medical terminology and appropriate graduate level writing is expected.
Your paper should be 3–4 pages (excluding cover page and reference page).
Your resources must include research articles as well as reference to non-research evidence-based guidelines.
Use APA format to style your paper and to cite your sources. Your source(s) should be integrated into the paragraphs. Use internal citations pointing to evidence in the literature and supporting your ideas. You will need to include a reference page listing those sources. Cite a minimum of three resources.
NURS530 Advanced Physiology and Pathophysiology
Week 7 Assignment
Video Presentation
The purpose of this assignment is to demonstrate understanding through teaching and explanation. Begin by choosing one of the topics below, or propose a topic of your own interest from the assigned readings subject to instructor approval. Post your choice to the discussion board thread “Video Presentation Topics” as soon as you make your choice. You may not select a topic that has already been chosen by a classmate. The sooner you choose, the more options you will have.
For this assignment, you will produce a 4–7 minute audio-video presentation on your chosen topic.
In your presentation, include the following:
Include at least one type of visual aid in your presentation such as PowerPoint slides, diagrams, white board use, etc.
You are expected to explain the processes or concepts in your own words using references to support your explanations. Include a reference list at the end and cite references verbally or with on screen citations.
Use appropriate master’s level terminology.
Include all necessary physiology and/or pathophysiology in your explanation.
Use detailed explanations to teach or explain. Your audience is your classmates and professional colleagues.
Reference a minimum of two sources; you may cite your etext as a source. Use APA format to style your visual aids and cite your sources. Include a reference page in your video.
Your presentation must include both audio and visual components and be professional in nature.
Possible Topics:
Describe the pathophysiology for the vesiculobullous disorders, bullous pemphigoid, and pemphigus.
Describe the clinical manifestations and treatment options for psoriasis.
Distinguish between rubella and rubeola. What are the differences between them in pathology, manifestation, and treatment?
Provide an overview of common insect bites and parasites affecting children.
Develop a treatment plan for a child diagnosed with head lice.
Describe the cellular alterations associated with shock.
Compare and contrast the different types of shock: cardiogenic, hypovolemic, neurogenic (vasogenic), anaphylactic, and septic.
Define multiple organ dysfunction syndrome (MODS), discuss risk factors associated with MODS, explain the pathogenesis of MODS, and compare primary and secondary MODS.
Identify the clinical manifestations of MODS by organ system.
Compare and contrast assessment techniques used to determine the amount of burn injury.
Discuss burn shock and fluid resuscitation in burns and discuss common treatment methods for burn injuries. Also explain the three essential elements of survival of a major burn injury.
Compare compensated and uncompensated shock in children.Describe the common causes of scald injuries and contact, flame, electrical, and chemical burns in children and Identify factors contributing to the depth of burn injuries in children.
Explain and characterize the changes in the standard rule-of-nines for burns involving children.
Define and describe the pathophysiology of reperfusion injury.
Identify and discuss fluid resuscitation, wound management, pulmonary support, nutritional support, comfort management, and community reintegration of children with burns.
Propose a topic of your own interest from this week’s readings; however, it must be submitted to your instructor for approval.
You will post your finished presentation here for grading, and you will post a copy to the discussion board thread Final Video Presentations to be shared and reviewed with your classmates.
NURS530 Advanced Physiology and Pathophysiology
Week 8 Assignment
Extended Case Study
The purpose of the case study is to have you expand on the pathophysiological disease process by searching for evidence-based practice treatment and advanced practice nursing role implications related to the disease.
Read the case here.
Review the patient’s TB questionnaire. (Page 1)
(Page 2)
Conduct an evidence-based literature search to identify the most recent standards of care/treatment modalities from peer-reviewed articles and professional association guidelines (www.guideline.gov). These articles and guidelines can be referenced, but not directly copied into the clinical case presentation. Cite a minimum of three resources.
Answer the following questions:
What is the transmission and pathophysiology of TB?
What are the clinical manifestations?
After considering this scenario, what are the primary identified medical concerns for this patient?
What are the primary psychosocial concerns?
What are the implications of the treatment regimen, as far as likelihood of compliance and outcomes? Search the Internet to research rates of patient compliance in treatment of TB, as well as drug resistant TB.
Identify the role of the community clinic in assisting patients, particularly undocumented patients, in covering the cost of TB treatment. What resources exist for TB treatment in community health centers around the United States? Compare the cost for treatment between, subsidized as it would be for a community health center, and unsubsidized.
What are the implications of TB for critical care and advanced practice nurses?
The use of medical terminology and appropriate graduate level writing is expected.
Your paper should be 4–5 pages, (excluding cover page and reference page).
Your resources must include research articles as well as reference to non-research evidence-based guidelines.
Use APA format to style your paper and to cite your sources. Your source(s) should be integrated into the paragraphs. Use internal citations pointing to evidence in the literature and supporting your ideas. You will need to include a reference page listing those sources. Cite a minimum of three resources.
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