Describe the patterns in the following forest plot in Glenn et al 2022, which is an assessment of a plant-based diet and incident type 2 diabetes mortality related to milk product consumption.
Describe the patterns in the following forest plot in Glenn et al 2022, which is an assessment of a plant-based "Portfolio" diet and incident type 2 diabetes mortality related to milk product consumption. B. Based on your description, does it appear that the Portfolio Diet increases, decreases, or does not influence the risk of diabetes? Glenn AJ, Li J, Lo K, Jenkins DJA, Boucher BA, Hanley AJ, Kendall CWC, Shadyab AH, Tinker LF, Chessler SD, Howard BV, Liu S, Sievenpiper JL. The Portfolio Diet and Incident Type 2 Diabetes: Findings From the Women’s Health Initiative Prospective Cohort Study. Diabetes Care. 2022 Sep 26:dc221029. Supplemental Figure S3: Subgroup analyses of the association between low adherence (Q1) to high adherence (Q5) of the Portfolio Diet score and incident type 2 diabetes Subgroup Cases Total n HR (95% Cls) P for interaction All participants 12,406 130,495 0.87 (0.82, 0.93) Age category 0.16 <50-59 4,237 43,239 0.89 (0.80, 0.99) 60-69 5.825 58,745 0.83 (0.75, 0.91) 70+ 2.344 28,511 0.94 (0.82, 1.09) BMI category 0.91 <25 kg/m2 1,985 48,088 0.78 (0.67, 0.92) 25 to <30 kg/m2 3,878 45.678 0.93 (0.83, 1.04) >= 30 kg/m2 6,543 36,729 0.91 (0.83, 0.99) Family history of T2DM 0.45 Yes 5,680 39,705 0.91 (0.83, 0.99) No 3,124 85.027 0.84 (0.76, 0.91) Ethnicity 0.19 White 9,569 1 11,128 0.89 (0.83, 0.95) African American 1.709 10,029 0.73 (0.60, 0.87) Hispanic 616 4.466 0.87 (0.66, 1.15) Asian 340 3.424 0.89 (0.62, 1.29) Smoking status 0.04 Never 6,295 66,235 0.84 (0.77, 0.92) Past 5,136 55,330 0.93 (0.85, 1.03) Current 975 8,930 0.76 (0.58, 0.99) 0.8 1.2 1.6 2.0 Beneficial Association Harmful Association Abbreviations: BMI, body mass index; HR, hazard ratio; T2DM, type 2 diabetes mellitus. The hazard ratios are for comparing participants in Q1 (low adherence) to Q5 (high adherence) to the Portfolio Diet score. The Cox regression model was adjusted for age, ethnicity, education, marital status, hysterectomy history, BMI, physical activity, smoking, alcohol intake, region in the U.S, study arm, energy intake, hypertension status, family history of diabetes, hormone therapy use, and cholesterol lowering medication use. P for interaction is comparing participants in Q1 (low adherence) to Q5 (high adherence) to the Portfolio Diet score. Under/over energy reporters and those with baseline diabetes were excluded from the analysis.
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