After reading the abstracts obtained from a literature search of disease topic, describe each or respond to each item comprehensively and in detail.
After reading the abstracts obtained from a literature search of disease topic, describe each or respond to each item comprehensively and in detail.
SERUM COPPER, ZINC, AND IRON LEVELS IN PATIENTS WITH ALZHEIMER’S DISEASE: A
META-ANALYSIS OF CASE-CONTROL STUDIES.
Li DD1, Zhang W2, Wang ZY1, Zhao P1.
Abstract
Background: Many publications have investigated the association between metal ions
and the risk of Alzheimer’s disease (AD), but the results were ambiguous.
Aims: The objective of this study was to assess the association between the serum levels of metals
(copper/zinc/iron) and the risk of AD via meta-analysis of case-control studies.
Methods: We screened literatures published after 1978 in the Pubmed, Embase, Cochrane library,
Web of Science and ClinicalTrials.gov. Electronic databases. By using Preferred Reporting
Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, we performed a
systematic review of the 407 publications, there are 44 of these publications met all
inclusion criteria. The Review Manager 5.3 software was used to calculate available data
from each study. Results: Consistent with the conclusions of other meta-analysis, our
results demonstrated serum copper levels were significantly higher [MD = 9.27, 95% CI
(5.02-13.52); p < 0.0001], and the serum zinc levels were significantly lower in AD
patients than in healthy controls [MD = -6.12, 95% CI (-9.55, -2.69); p = 0.0005]. Serum
iron levels were significantly lower in AD patients than in healthy controls after excluded
two studies [MD = -13.01, 95% CI (-20.75, -5.27); p = 0.001].
Conclusion: The results of our meta-analysis provided rigorous statistical support for the association of the serum
levels of metals and the risk of AD, suggesting a positive relationship between the serum
copper levels and AD risk, and a negative relationship between the serum zinc/iron
levels and AD risk.
1. What is the epidemiologic study design?
2. (a) Identify the exposure(s) of interest (independent variables) and (b) the
outcome(s) (dependent variables) of interest in the study.
3. (a) Suggest at least one possible bias (systematic error) that might be present in
each study. Pay particular attention to how subjects were selected, and what
information was gathered from them and how it was collected. (b) Explain
specifically how this could introduce bias into the study.
4. (a) Suggest one or more possible confounding factors related to the data
collected and analyzed in the study, and (b) explain how it/they might confound
interpretation of the authors’ findings.
5. (a) Suggest at least one other epidemiologic study design that could address the
same question(s), and (b) discuss the relative strengths and limitations of the
other study design compared to the one actually used.
Collepals.com Plagiarism Free Papers
Are you looking for custom essay writing service or even dissertation writing services? Just request for our write my paper service, and we'll match you with the best essay writer in your subject! With an exceptional team of professional academic experts in a wide range of subjects, we can guarantee you an unrivaled quality of custom-written papers.
Get ZERO PLAGIARISM, HUMAN WRITTEN ESSAYS
Why Hire Collepals.com writers to do your paper?
Quality- We are experienced and have access to ample research materials.
We write plagiarism Free Content
Confidential- We never share or sell your personal information to third parties.
Support-Chat with us today! We are always waiting to answer all your questions.
