For this Assignment, you evaluate drug treatment plans for patients with various disorders and justify drug therapy plans based on patient history and diagnosis.
Case studies are a useful way for you to apply your knowledge of pharmacokinetics and pharmacodynamic aspects of pharmacology to specific patient cases and health histories.
For this Assignment, you evaluate drug treatment plans for patients with various disorders and justify drug therapy plans based on patient history and diagnosis.
Resources
Be sure to review the Learning Resources before completing this activity.
Click the weekly resources link to access the resources.
WEEKLY RESOURCES
Learning Resources
Required Readings
Note: If you do not purchase Lecturio, please consult these resources for this week.
Rosenthal, L. D., & Burchum, J. R. (2025). Lehne’s pharmacotherapeutics for advanced practice nurses and physician assistants (3rd ed.). Elsevier.
Chapter 37, “Diuretics” (pp. 285–292)
Chapter 38, “Drugs Acting on the Renin-Angiotensin-Aldosterone System” (pp. 292–303)
Chapter 39, “Calcium Channel Blockers” (pp. 303–308)
Chapter 40, “Vasodilators” (pp. 308–311)
Chapter 41, “Drugs for Hypertension” (pp. 311–320)
Chapter 42, “Drugs for Heart Failure” (pp. 321–332)
Chapter 43, “Antidysrhythmic Drugs” (pp. 333–344)
Chapter 44, “Prophylaxis of Atherosclerotic Cardiovascular Disease: Drugs That Help Normalize Cholesterol and Triglyceride Levels” (pp. 345–359)
Chapter 45, “Drugs for Angina Pectoris” (pp. 360–367)
Chapter 46, “Anticoagulant and Antiplatelet Drugs” (pp. 368–384)
Required Media
To Prepare:
Review the case study posted in “Announcements” by your Instructor for this Assignment
Review the information provided and answer questions posed in the case study
When recommending a medication, write out a complete prescription for the medication
Whenever possible, use clinical practice guidelines in developing your answers when possible
Include at least three references to support your answer and cite them in APA format.
By Day 7 of Week 1
Submit the Assignment.
submission information
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In Week 2, we will continue our pharmacology journey and apply the concepts to the cardiovascular system. Pharmacodynamics and pharmacokinetics are the two branches of pharmacology. Remember, pharmacokinetics describes what the body does to the drug through absorption, distribution, metabolism, and excretion (ADME), whereas pharmacodynamics describes what the drug does to the body.
When selecting drugs and determining dosages for patients, it is essential to consider individual patient factors that might impact the patient’s pharmacokinetic and pharmacodynamic processes. These patient factors include genetics, gender, ethnicity, age, behavior (ie diet, nutrition, smoking, alcohol, illicit drug abuse), and/or pathophysiological changes due to disease.
WEEK 2 ASSIGNMENT (covers weeks 1 & 2)
Submit your Assignment by Day 7 of Week 2 (Sunday night, 11:59 pm ET). The week 2 assignment covers material from weeks 1 and 2.
Directions: For EACH of the scenarios below, answer the questions using your required learning resources, Medscape, and clinical practice guidelines (ie AHA, ACC, ADA, GINA). When recommending medications, write out a complete prescription for each medication. What order would you send to a pharmacy? Include drug, dose, route, frequency, # dispensed (days supply), refills, special instructions etc. Also state if you would continue, discontinue or taper the patient’s current medications (if applicable). Use at least 3 sources for each scenario and cite sources using APA format. LIST REFERENCES AFTER EACH SCENARIO.
SCENARIO 1
What are the errors in the following prescriptions (1 per prescription)? Rewrite each prescription correctly. What is each medication’s classification and mechanism of action (MOA)?
· Repatha 140 mg IV every 2 weeks #1 1 RF
· Hyzaar (losartan/hydrochlorothiazide) 50/25 mg PO daily #30 3 RF
· digoxin 1.25 mg PO daily #30 1 RF
· hydralazine/isosorbide mononitrate (BiDil) 37.5 mg/20 mg PO every 8 hours #90 1 RF
· clonidine 0.3 mg patch PO once weekly #4 1 RF
SCENARIO 2
A patient with stable angina is prescribed nitroglycerin. The provider avoids oral tablets and instead chooses a sublingual or transdermal formulation. Why is oral nitroglycerin not clinically useful? Discuss how first-pass metabolism affects nitroglycerin’s bioavailability and define both terms. Identify the route of administration with 100% bioavailability and explain how alternative routes overcome the first pass effect. Include a sample prescription for nitroglycerin.
SCENARIO 3
Where are the majority of cytochrome P450 (CYP) enzymes located? Using the Drugs.com pill identifier, enter the following characteristics to identify the medication AND strength. What CYP enzyme metabolizes this medication? How can this information be applied to medication therapy management? Write a sample prescription for the identified medication and strength.
Imprint (E 137) Shape (Round) Color (Pink) Form (Tablet) Scoring (None)
SCENARIO 4
KU is a 47-year-old male following up on his labs that were drawn last week. He smokes 1 pack per day. He is currently on lisinopril 40 mg po daily, liraglutide (Victoza) 0.6 mg subcutaneously once daily and St. John’s Wort. Fasting lipid profile shows total cholesterol 260 mg/dL, LDL 180 mg/dL, HDL 43 mg/dL, and TG 185 mg/dL. He is 5’9” and weighs 204 lbs. What treatment plan would you implement for KU? What are GOAL Total Cholesterol (TC), HDL, LDL, and Triglyceride levels for KU? What is his BMI per Medscape calculator? What patient monitoring and education would you provide? How many risk factors for coronary artery disease does this patient have? Identify them specifically.
Note on Assignment Attempts
Students are expected to review their work and submissions of work carefully prior to due dates. Unless otherwise approved by the faculty, students are allowed one submission of graded work per assignment. While the classroom allows for multiple submissions, once an assignment is graded, submissions will no longer be accepted
unless approved by the faculty. If an assignment is submitted prior to the assignment deadline and has not yet been graded, then students may submit a revised assignment prior to the assignment deadline. Once the deadline has passed, resubmission is not permitted.
Late Assignment Policy
Students are expected to submit assignments by the due dates noted in the course and welcome announcement. In extenuating circumstances, such as illness, the student must contact the instructor as soon as possible to discuss the situation. In those circumstances, faculty will determine the appropriate course of action for the student. Depending on the situation, these actions may include recommendations to drop the course (if within the university drop/withdrawal period), acceptance of some or all of the overdue assignments with or without penalties, or failure to accept assignments.
Assignments submitted late without the prior agreement of the instructor, outside of an emergency absence, or in violation of agreements for late submission, will receive a grade reduction for the assignment amounting up to 20%. Each day late will result in a 4% point deduction up to day 5. After 5 days, the assignment will be graded a zero.
However, ALL assignments, quizzes, and exams must be completed to pass the course.
Wishing you much success,
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