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July 28, 2024

indomethacin and Mechanism of Action Synthesis

Can you give an overview of the overall synthesis involved in producing the pharmaceutical?

Are you able to highlight major changes in the functional groups in the overall synthesis?

Can you highlight 2 reaction steps?

Look at changes in the functional groups in the 2 highlighted reaction steps, What are the reagents required to achieve the change?

What is the name of the reaction involved in the 2 highlighted steps? Discuss the mechanism of action in the body and the metabolism of the pharmaceutical.

Are there any side effects of the pharmaceutical?

How does the drug change within the body?

Can you give at least one major metabolite of the pharmaceutical?

Can you give any structural changes that happen with this drug in the body? (e.g. an

example of the change from drug to metabolite)

What organ in the body breaks down the drug?

Is the drug converted into another form in the body to become active?

What are the side effects of the pharmaceutical?

Is one Stereoisomer more dangerous/effective/potent than the other?

How is the drug excreted, and in what form?

Provide images of the synthesis reaction and highlight the functional group changes.

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