powerpoint slides and presentation about Cardiac Tissue Engineering

April 30, 2024 Cardiac Tissue Engineering Kirsten Gauvey, Gabriella Chung, Joel Aboagye, & Mohammad Wahdan Overview: Table of contents 01 Introduction & Background 04 Future works & Conclusion 02 Current Advances 05 Acknowledgments & References 03 Prospects & Outlook 01 Introduction & Background Introduction- Cardiac Tissue Engineering Cardiac tissue engineering (CTE) is a field that merges principles from engineering, biology, and medicine to artificially create functional artificial heart tissue using various decellularization and cell culture methods. ● ● https://ideas.ted.com/ a-ghost-heart/ Why is CTE needed? allows for innovative treatments for heart diseases, such as myocardial infarction and heart failure, which currently lack effective regenerative solutions. By developing tissue constructs that mimic the structure and function of native heart tissue, cardiac tissue engineers aim to regenerate Cardiac tissue for Figure 1: heart after decellularization. REF[] several medical applications Introduction- Cardiac TE Medical Problems: Tissue Engineering Applications: Patients who suffer from heart diseases, Tissue engineers use CTE to ● regenerate damaged myocardium ● provide platforms for drug testing and disease modeling ● reduce dependency on donor organs. 02 Current Advances Current understanding Current understanding: What are the current advances and challenges in this field? What methods are primarily used How promising is cardiac TE? About/ methods of CTE Decellularization Bioprinting Scaffolds Tissue regeneration etc… 03 Prospects & Outlook 06 Future Works & Conclusion Future works 1. 2. 3. 4. 5. Advanced cell sources: Induced pluripotent stem cells(iPSCs) to minimize rejection risks. Vascularization strategies. In vitro maturation techniques Integration with Advanced manufacturing techniques (3D printing, microfluidics and tissue-on- a- chip platforms). Biomaterials with enhanced functionality Conclusions/ Take home points Point 1 Point 2 Point 3 overall Acknowledgements Contributions Kirsten: Introduction & Background Gabriella: Prospects & Outlooks Joel: Current advances & understanding Mohammad: Future Works & Conclusion References [1] Shi, X., Zhang, S., Liu, Y., Brazile, B., Cooley, J., Butler, J. R., … & Liao, J. (2023). Spatial distribution and network morphology of epicardial, endocardial, interstitial, and Purkinje cellassociated elastin fibers in porcine left ventricle. Bioactive Materials, 19, 348-359. [2] Shi, X. BMEN 4314 Tissue Engineering Lab, “TE Decellularization Lab Manual”, Decellularization of Pig Heart muscle fibers. University of North Texas Biomedical Engineering Department. April 2024. References Thanks! Do you have any questions? CREDITS: This presentation template was created by Slidesgo, and includes icons by Flaticon, and infographics & images by Freepik