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April 22, 2024

A 22-year-old male presents for an evaluation. His history is significant for opioid use disorder. The patient uses one gram of heroin intravenously daily. The

A 22-year-old male presents for an evaluation. His history is significant for opioid use disorder. The patient uses one gram of heroin intravenously daily. The last dose of heroin was two hours ago. The patient denies any restlessness, nausea, vomiting, or diarrhea. His vital signs include blood pressure 120/80 mmHg, pulse 72bpm, respiratory rate 18/min, and temperature 37 C (98.6 F). Physical exam was normal. The patient wants to stop heroin and asks for medication-assisted treatment. Which one of the following medications may cause precipitated withdrawal if started at this point? A. Buprenorphine B. Clonidine C. Methadone D. Lofexidine

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