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A patient presents to the clinic complaining of chronic exhaustion. HPI reveals that the patient feels fine in the morning

A patient presents to the clinic complaining of chronic exhaustion. HPI reveals that the patient feels fine in the morning, however as the day progresses, he feels weak. Physical examination shows ptosis (lazy eyelid), and difficulty smiling. Muscle resistance is low. Further tests reveal that the patient is suffering from Myasthenia Gravis, which is an autoimmune disorder that destroys acetylcholine receptors in the neuromuscular junction. • Please describe the pathophysiology (what is wrong physiologically) of this disease, starting from the neuromuscular junction. Why is this patient feeling weak? 87

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