Genomics

There is a wealth of information on the web about genomics. There are many websites that will be helpful to you during this course and beyond. The purpose of this discussion activity is to become familiar with a variety of online sources of information about genomics.

Write your website review in the format shown below. Your review must contain the following sections:

Your Genome

http://www.yourgenome.org/

Why I Chose this Site:

Whose Site is it?

What is the Purpose of this Site?

How is this Site Funded?

Description of Site:

My Opinion of this Site:

Responding to your classmates’ reviews:

Assignment 2 – 1 1/2 pages

1. (Optional: Play with this PUNNETT SQUARE CALCULATOR to get used to creating Punnett squares.)

Invent a unique entertaining pretend human trait with a dominant and recessive allele (for example: beer belly vs. six-pack). Define your traits, indicate which is dominant and which is recessive. Choose symbols for each trait (choose one letter and use its capital form for the dominant trait and the lower case form for the recessive trait). Create Punnett squares for the following situations:

Homozygous dominant individual vs. homozygous recessive individual

Homozygous dominant individual vs. heterozygous individual

Heterozygous individual vs. homozygous recessive individual

Heterozygous individual vs. heterozygous individual

Below each Punnett square, give the genotypic ratio and phenotypic ratio of the offspring.

2. Study the following websites:

Common pedigree symbols: https://medicine.duke.edu/divisions/general-internal-medicine/precision-medicine

Pedigree Analysis: https://www.ndsu.edu/pubweb/~mcclean/plsc431/mendel/mendel9.htm

Drawing Your Family Tree: https://cbiit.github.io/FHH/html/index.html

Human Pedigree Analysis: https://www.khanacademy.org/science/ap-biology/heredity/non-mendelian-genetics/a/hs-pedigrees-review

a. Describe and define the symbols used in a human pedigree.

b. Explain clues in a pedigree that will give an indication of the following types of traits:

Autosomal Recessive

Autosomal Dominant

X-linked Recessive

Assignment 3

Study the case study about hemophilia: (Attached) Hemophilia: “The Royal Disease”

Add your answers to the following questions from the case study and then submit this completed case study report form.

1. (a) What is the probability that her other son was hemophilic?

(b) What is the probability that her daughter was a carrier? Hemophilic?

(c) What is the probability that both children were normal?

2. (a) Looking at the pedigree of the royal family, identify which of Beatrice’s children received the hemophilic gene; why can you make this conclusion?

(b) Notice that Beatrice’s daughter, Eugenie, married King Alfonso XIII of Spain and had six children, one of whom was the father of Juan Carlos, the current King of Spain. Would you predict that Juan Carlos was normal, a carrier, or a hemophilic?

3. (a) What are the probabilities that all four of the girls were carriers of the allele hemophilia?

(b) Supposing Alexis had lived and married a normal woman, what are the chances that his daughter would be a hemophiliac?

(c) What are the chances his daughters would be carriers?

(d) What are the chances that his sons would be hemophiliacs?

4. (a) According to Eugene’s argument, what was the likely hemophilic status of Eugene’s mother and grandmother? What about his father and grandfather? Is this argument plausible?

(b) How plausible is it that Eugene inherited both hemophilia and the last name from the royal family? (Hint: Look how each of them is passed from generation to generation.)

5. If you learned that one of the two sons was a hemophiliac, what are the possible explanations for this event?

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