OSH 4302 Unit III Assignment- Toxicology

For this assignment, you will be accessing the Unit III Assignment Worksheet and answering the questions. The responses should be in complete sentences and utilize proper APA citations for referenced information. Explain how results were derived for any math problems.

Once you have answered all of the questions on the worksheet, please upload into the assignment area in Blackboard for grading.

1. In your own words, compare the following pairs of terms and then provide an example of each.

a. Mechanism of action versus mode of action

b. Local effect versus systemic effect

c. Statistical significance versus biological significance

2. Compare chronic exposure to acute exposure. Research and discuss at least one manufacturing

toxicant that causes adverse effects from both chronic exposure and acute exposure. Identify the

toxicant, what it is used for in manufacturing, how exposure occurs and the observable adverse

effects that it causes.

3. Using the dose-response curve above answer the following questions:

a. Which substance has the highest potency? Explain your answer.

b. Define NOEL. What is the NOEL range of substance B?

c. What is the ED50 and TD50 of substance A? How did you determine these values?

d. The therapeutic index of substance B is 9. Comparing substance A to substance B, which

one would be considered safer? Explain your answer.

e. At what dose is the maximum toxic effect of substance A observed? Explain your answer.

f. At what dose is threshold reached for substance B? What is the threshold of a

substance?