Accuracy When drawing on external resources such as lecture, the textbook, or empirical facts, those resources should be employed in a way that is true to the source material.
Case Analysis Assignment Instructions Below are 2 cases. Each is accompanied by some questions. Choose 1 case and answer the questions in it in appropriate detail, defending your answer and drawing on the resources developed in lecture and in the textbook where appropriate. A maximum of one single-spaced page should be used for each case. There is no enforced minimum. Please indicate at the top of the paper which case you have chosen to analyze. All assignments are to be submitted via BlackBoard. You can either write your assignment in a word processor (preferred) and upload it or you may type your response directly into the assignment. Grading Information Each case will be graded out of 10 points. While there is no formal rubric, answers should aim at the following: 1. Accuracy When drawing on external resources such as lecture, the textbook, or empirical facts, those resources should be employed in a way that is true to the source material. 2. Precision Technical details and philosophical concepts should be used carefully and in a way that demonstrates your comprehension. 3. Concision Answers should not contain fluff or irrelevant detail. Do not add additional words, include irrelevant details, or use hyperbole. 4. Depth When defending or explaining your own views, provide sufficient detail to make a plausible case to someone who might disagree with you. Where appropriate, avoid simple, single-sentence answers that do not demonstrate your grasp of the materials. 5. Clarity Demonstrate your understanding of materials with clear explanations. Aim to make your answer understood to an audience that is not familiar with the text or lecture materials. Cases Case 1 You are a graduate student in behavioral pharmacology, and your lab is conducting a drug discrimination study, an operant procedure in which rats are trained to identify drugs with stimulus properties similar to those of a training drug. The primary goal of the present study is to test several experimental compounds for their similarity to clozapine, an important treatment for schizophrenia. The compounds to be tested have been sent to your advisor as part of a contract awarded from a drug company. The generalization testing portion of the study is nearing completion, with only one dose-response curve left to obtain. During routine feeding, you notice that 8 of the 10 animals in the study have developed tumor-like growths at the site of injection on the stomach. Additionally, these animals have begun losing weight. Finally, you note that the animals do not exhibit any behaviors suggesting that they are experiencing any discomfort. Concerned, you mention the growths and weight loss to your advisor, who instructs you to continue with generalization testing. He is concerned that having to train a new set of animals in order to test one drug would waste large amounts of research time and resources and may cause problems in interpreting the results. He further states that the animals will be
euthanized as soon as the testing phase of the study is completed in less than a month and that the animals will be fine until then. Is your advisor’s suggested course of action legally and ethically appropriate? If not, what should be done in this case? What are your obligations in this situation? Case 2 Dr. Carley Featherstone is disappointed that the IACUC has rejected her research protocol because it involves the mouse ascites method of monoclonal antibody production. She appeals to the IACUC, citing her long use of this practice, prior approval to use the method at her previous institution in another state, and the loss of time that an immediate switch to in vitro methods would entail. She asks for permission to continue using the ascites method for 3 years while she phases in the in vitro production methods. The IACUC denies the appeal. She then resubmits the protocol, reporting that since she has found a commercial source for the monoclonal antibody she no longer needs to produce it herself. The protocol is quickly approved. Dr. Emanuel Louis, a member of the IACUC, has a conversation with Dr. Featherstone a few months later. She tells him that her commercial source is a custom contract lab that she has engaged to produce the antibody using her cell lines and to her specifications (i.e., using the mouse ascites method). Is Dr. Featherstone’s solution legal? Is it ethical? Why or why not? Dr. Louis comes to you for advice. Does he have any obligation to report this information to the IACUC?
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