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February 10, 2023

Valproic acid (VPA) is a medication used to treat epilepsy. Assume VPA exhibits “one compartment” pharmacokinetics. In adult patients, the average values of VPA clearance and volum

Valproic acid (VPA) is a medication used to treat epilepsy. Assume VPA exhibits “one compartment” pharmacokinetics. In adult patients, the average values of VPA clearance and volume of distribution are 0.5 L/hr and 9L, respectively. What is the rate of elimination (in mg/hr) when the plasma concentration is 29.5 mg/L?

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