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alpha adrenergic receptor agonists elicit vascular smooth muscle (VSM) contraction. Drug 1 is an alpha 1-adrenergic receptor agonist (increase contraction). Drug 2 is a non-competitive, non sele

alpha adrenergic receptor agonists elicit vascular smooth muscle (VSM) contraction. Drug 1 is an alpha 1-adrenergic receptor agonist (increase contraction). Drug 2 is a non-competitive, non selective, alpha adrenergic receptor agonist (decrease contraction). If drug 2 is added to drug 1 which of the following responses would you expect to observe?

A. Drug 2 will NOT decrease the response to an alpha2-adrenergic receptor agonist.

B. The decreased VSM contraction observed in the presence of drug 2 can be overcome by increasing the concentration of Drug 1

C. Drug 2 will decrease the potency of drug 2 with regard to contraction of VSM

D. Drug 2 will decrease the maximal response (VSM contraction) or Emax of Drug 1

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