The argument for those in favor of launching RCT’s using vaccines during epidemics or pandemics
Adebamowo, C., Bah-Sow, O., Binka, F., Bruzzone, R., Caplan, A., Delfraissy, J. F., Heymann, D., Horby, P., Kaleebu, P., Muyembe Tamfum, J.J., Olliaro, P., Piot, P., Tejan-Cole, A., Tomori, O., Toure, A., Torreele, E., and Whitehead, J. (2014). Randomised controlled trials for Ebola: practical and ethical issues. Lancet (London, England), 384(9952), 1423-1424. doi:10.1016/S0140-6736(14)61734-7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392883/
Describe (generally) what the purpose of this article
2. What is the argument for those in favor of launching RCT’s using vaccines during epidemics or pandemics?
3. What is the argument for those in who are opposed to launching RCT’s using vaccines during epidemics or pandemics?
4. Do you object or favor the launch of RCT’s using investigational drugs (or vaccines) during pandemics/epidemics? Why or why not?
Tuskegee Syphilis Study
Brandt, A. M. (1978). Racism and research: the case of the Tuskegee Syphilis Study. Hastings center report, 21-29. https://dash.harvard.edu/bitstream/handle/1/3372911/Brandt_Racism.pdf?sequence
5. Describe the purpose of the study.
6. Who initiated the study
7. What type of study design is used? Is it prospective, retrospective, or both? Is this an appropriate design to investigate the main purpose of the study? Why or why not?
8. What is the sample size used for this study? Describe the study sample by race/ethnicity, sex, age, and geographic location.
9. Comment on the ethics for the overall study and methodology.
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