The “Ominous Octet” phrase coined by Dr. Ralph DeFronzo refers to eight main core defects contributing to hyperglycemia, occurring with diabetes.

Ominous Octet

The “Ominous Octet” phrase coined by Dr. Ralph DeFronzo refers to eight main core defects contributing to hyperglycemia, occurring with diabetes.

In a minimum of 175-300 words, provide seven main core defects contributing to hyperglycemia. One main core is already provided in the example below.

Include the following in your response:

Organ: The organ that is contributing to the hyperglycemia

Defect: A phrase to describe the defect

Drug Class: At least one drug class (not drug name)that works on the defect

Mechanism of Action: Explain the mechanism of action

Why is it important for an FNP to understand each defect?

Example

Organ: Pancreas

Defect: Decreased beta cell production

Drug Class: Sulfonylurea

Mechanism of Action: Stimulates release of insulin from beta cells

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