Can we infer that aspirin use is causally related to reduced risk of death after myocardial infarction

Read the following text from this hypothetical study and respond to the question.  Apply at least 3 of the guidelines for judging whether an observed association is causal listed here:

-Temporal relationship

-Strength of the association

-Dose-response relationship

-Replication of the findings

-Biologic plausibility

-Consideration of alternate explanations

-Cessation of exposure

-Consistency with other knowledge

-Specificity of the association

Text: 

Fifteen studies, including two randomized trials, five cohort studies, and eight retrospective case-control studies have investigated the association between aspirin use and mortality after myocardial infarction.  All but one agrees that there in an inverse association between aspirin use and mortality; aspirin reduced mortality by almost 50%.  Aspirin reduces platelet aggregation and hence risk of clot formation in coronary arteries. Can we infer that aspirin use is causally related to reduced risk of death after myocardial infarction?  Discuss 

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