A 59-year-old white man visited his primary care provider because of his need to urinate frequently and urgently.
A 59-year-old white man visited his primary care provider because of his need to urinate frequently and urgently. Over the last several years, his urine output had been in small volumes, with a decreasing flow rate.
On physical examination, the patient had an enlarged prostate with a smooth, uniform surface. A PSA assay was ordered. The results of the current and previous assays were as follows (reference range, 0-3.5 ng/mL):
• Current PSA level, 5.5 ng/mL
• PSA level 1 year ago, 2.3 ng/mL
Questions
1. Is the change in the patient’s PSA results in 1 year significant?
2. What is the clinical significance of the patient’s results?
3. What is the expected follow-up procedure for a patient with this profile?
4. After a radical prostatectomy, what PSA values would be expected?
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