What is the first-line therapy for osteoarthritis and the mechanism of action?

Order Instructions

Sally is a 50-year-old female who has been a jogger for

several years. She has recently been diagnosed with

osteoarthritis. She has been taking ibuprofen for 3 months

but states that “it does not help” and hurts her stomach.

The health care provider prescribes celecoxib (Celebrex) 100

mg orally twice a day.

a. What is the first-line therapy for osteoarthritis and the

mechanism of action?

b. Sally expresses concern about all the recent news about

heart problems and celecoxib (Celebrex). What information

should be included in a teaching plan to help her

understand about taking celecoxib and the benefits and

risks?

c. Ibuprofen and celecoxib are both nonsteroidal anti-

inflammatory drugs. Explain how they are similar and

different

Submission Instructions:

Your initial post should be at least 500 words, formatted and cited in current APA style with support from at least 2 academic sources. Your initial post is worth 8 points.

You should respond to at least two of your peers by extending, refuting/correcting, or adding additional nuance to their posts. Your reply posts are worth 2 points (1 point per response.)

All replies must be constructive and use literature where possible.