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October 26, 2022

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

According to below article:

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

13 Jan 2022Vol 375, https://www.science.org/doi/10.1126/science.abj8222

1. If the outcome is multiple sclerosis, is EBV infection: a) necessary, b) sufficient, or c) component cause? Justify your answer, knowing that more than one of these options may be true.

2. Can you design a study to directly test the causal effects of EBV infection on multiple sclerosis incidence in humans? Why or why not?

3. . Imagine the USPSTF is considering screening for EBV infection in order to identify those at highest risk for multiple sclerosis. What grade would you assign to the evidence in support of such a screening? Justify your answer.

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