Describe the Punnett Square and what it used to predict. What are the limitations of the Punnett Square?

NSG5003 Advanced Pathophysiology

Week 3 Discussion

Describe the Punnett Square and what it used to predict. What are the limitations of the Punnett Square?

Mom is a carrier for hemophilia but does not have the disease.

Dad does not have hemophilia

Using the Punnett Square, answer the following questions:

What is the probability a female offspring developing hemophilia?

What is the probability of a female offspring being a carrier for hemophilia?

What is the probability of a male offspring developing hemophilia?

What is the probability of a male offspring being a carrier developing hemophilia?

What is the probability of any offspring developing hemophilia?

Explain why only some offspring would develop the disease?

Response #1: If this were about Cystic Fibrosis, how would the responses be different to the questions in the Initial Post? Give a detailed explanation supporting your response.

Response # 2 Down Syndrome is another genetic disorder. Why is the Punnett Square not a good tool for predicting if offspring will have Down Syndrome? Why does the risk for Down’s Syndrome increase with maternal age?

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