A.S. was recently diagnosed with Hodgkin disease and scheduled for a staging procedure. His previous axillary lymph node biopsy result was positive for Reed-Sternberg cells.

PATH370 Pathophysiology

Week 2 In Class Assignment

Hodgkin disease

A.S. was recently diagnosed with Hodgkin disease and scheduled for a staging procedure. His previous axillary lymph node biopsy result was positive for Reed-Sternberg cells. The surgeon charted results of the staging procedure as “stage I.”

What is the purpose of the staging procedure for A.S.?

How does Hodgkin lymphoma spread in the body, and what does “stage I”signify for A.S.?

What is the difference between Hodgkin disease and non-Hodgkin lymphoma?

What is the prognosis and predicted therapy for A.S. now that he has been diagnosed with stage I Hodgkin disease?

What side effects might A.S. expect from this therapy?

Case 2 E.O. is an 8-year-old girl with a history of asthma and allergy to bee stings. She has been brought to the clinic complaining of a throat infection. Her health care provider prescribes a course of penicillin to manage her current infection and cautions her parents to watch her closely for a reaction.

Discussion Questions

What type of reaction is the health care provider concerned about and why?

Explain the role of IgE and mast cells in type I hypersensitivity reactions. Why might E.O. react adversely to the antibiotic with the first use?

What would you tell E.O.’s parents to look for when they are assessing for a reaction?

What would you suggest the parents do if a reaction does occur?

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