A primary effector cell of the type I hypersensitivity response is monocytes.
PATH370 Pathophysiology
Week 2 Understanding Assignment
Question 1A primary effector cell of the type I hypersensitivity response is
monocytes.
mast cells.
neutrophils.
cytotoxic cells.
Question 2An important mediator of a type I hypersensitivity reaction is
complement.
antigen–antibody immune complexes.
T cells.
histamine.
Question 3Peripheral edema is a result of
arterial insufficiency.
venous thrombosis.
hypertension.
atherosclerosis.
Question 4The Philadelphia chromosome is a balanced chromosome translocation that forms a new gene called
bcr-abl.
Rb.
p53.
ARA-c.
Question 5Which form of leukemia demonstrates the presence of the Philadelphia chromosome?
ALL (acute lymphoid leukemia)
CLL (chronic lymphoid leukemia)
AML (acute myeloid leukemia)
CML (chronic myeloid leukemia)
Question 6Risk factors for atherosclerosis include
female gender.
hyperlipidemia.
high-protein diet.
low-fiber diet.
Question 7The hypersensitivity reaction that does not involve antibody production is type
I.
II.
III.
IV.
Question 8Which clinical finding is indicative of compartment syndrome?
Peripheral edema
Absent peripheral pulses
Redness and swelling
Atrophy of distal tissues
Question 9A child with a history of recent strep throat infection develops glomerulonephritis. This is most likely a type _____ hypersensitivity reaction.
I
II
III
IV
Question 10What is the effect on resistance if the radius of a vessel is halved?
Resistance doubles.
Resistance decreases by a factor of 16.
Resistance decreases by half.
Resistance increases by a factor of 16.
Question 11A 5-year-old patient’s parents report loss of appetite and fatigue in their child. The parents also state that the child refuses to walk as a result of pain. The child’s most likely diagnosis is
ALL (acute lymphoid leukemia)
CLL (chronic lymphoid leukemia)
AML (acute myeloid leukemia)
CML (chronic myeloid leukemia)
Question 12The goal of long term heparin for the management of a deep vein thrombosis is to
relieve edema.
prevent clot dislodgement.
dissolve the thrombus.
prevent further clot formation.
Question 13The patient is a 12-year-old boy diagnosed with acute lymphoid leukemia (ALL). As part of treatment, the patient must undergo several weeks of chemotherapy. The most serious complication of chemotherapy is
vomiting.
anemia.
alopecia.
infection.
Question 14 Which disorder is associated with a type III hypersensitivity mechanism of injury?
Systemic lupus erythematosus
Graves disease
Erythroblastosis fetalis
Seasonal allergic rhinitis
Question 15The liver is responsible for the synthesis of coagulation factors, with the exception of part of VIII.
True
False
Question 16Velocity of blood flow is measured in
centimeters per second.
millimeters per minute.
yards per hour.
kilometers per minute.
Question 17A diagnostic laboratory finding in myeloma is
Bence Jones proteins in the urine.
decreased platelet count.
increased IgM antibody titer.
elevated blood glucose levels.
Question 18The most common primary immune deficiency that affects only B cells is
DiGeorge.
Bruton agammaglobulinemia.
Wiskott–Aldrich.
selective IgA.
Question 19Patients with immunodeficiency disorders are usually first identified because they
run high fevers.
have unusually high WBC counts.
develop brain infections.
develop recurrent infections.
Question 20The relationship of blood flow (Q), resistance (R), and pressure (P) in a vessel can be expressed by which equation?
Q = P/R
Q = R/P
R = PQ
P = Q/R
Question 21Red blood cells differ from other cell types in the body, because they
contain cytoplasmic proteins.
have no cytoplasmic organelles.
have a longer life span.
contain glycolytic enzymes.
Question 22Widespread activation of the clotting cascade secondary to massive trauma is called
hemophilia B.
disseminated intravascular coagulation (DIC).
Hageman disease.
idiopathic thrombocytopenia purpura.
Question 23A normal bleeding time in association with normal platelet count, and increased prothrombin time (PT) and INR, is indicative of
vitamin K deficiency.
hemophilia B.
hemophilia A.
idiopathic thrombocytopenia.
Question 24Treatment for hemophilia A includes
heparin administration.
factor IX replacement.
factor VIII replacement.
platelet transfusion.
Question 25Two of the most serious oncology emergencies associated with non-Hodgkin lymphoma are obstruction of the superior vena cava and compression of the spinal cord.
True
False
Question 26The activated partial thromboplastin time (aPTT) is a measure of the integrity of
the extrinsic pathway.
the intrinsic pathway.
factor VIII synthesis.
plasminogen.
Question 27The primary source of erythropoietin is provided by the
bone marrow.
kidney.
lung.
liver.
Question 28The final step in clot formation is
conversion of prothrombin to thrombin.
platelet degranulation and adhesion.
conversion of fibrinogen to fibrin.
clot retraction.
Question 29The megakaryocyte is a precursor to
factor IX.
white blood cells.
red blood cells.
platelets.
Question 30Patients who experience anemic episodes when exposed to certain drugs most likely have
thalassemia.
spherocytosis.
sickle cell anemia.
glucose-6-phosphate dehydrogenase deficiency.
Question 31A patient is diagnosed with a tortuous blood vessel of the right hand that bleeds spontaneously. This patient presents with
petechiae.
purpura.
telangiectasia.
thrombocytosis.
Question 32The most effective therapy for anemia associated with kidney failure is
iron administration.
high-protein diet.
erythropoietin administration.
vitamin B12 and folate administration.
Question 33Pernicious anemia is caused by a lack of
iron.
intrinsic factor.
folate.
erythropoietin.
Question 34ysfunction of which organ would lead to clotting factor deficiency?
Liver
Kidney
Spleen
Pancreas
Question 35The conversion of plasminogen to plasmin results in
clot retraction.
fibrinolysis.
platelet aggregation.
activation of thrombin.
Question 36The movement of blood through the vascular system is opposed by the force of
viscosity.
the vessel length.
the vessel radius.
resistance.
Question 37When systemic vascular resistance is decreased, blood flow
increases.
decreases.
stays the same.
moves to the extremities.
Question 38A cause of thrombocytopenia includes
hypoxemia.
reduced erythropoietin.
chemotherapy.
secondary polycythemia.
Question 39The arterial oxygen content (CaO2) for a patient with PaO2 100 mm Hg, SaO2 95%, and hemoglobin 15 g/dL is _____ mL oxygen/dL.
19.4
1909.8
210
21.05
Question 40What is necessary for red blood cell production?
Phosphate
Iron
Magnesium
Calcium
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