my professor asked me to make a short proposal draft according to the proposal and articles that are provided here? i would someone who has expertise to read ?and write a ?short

Title: DTI tractography in brain tumour patients with headache and non-headache

phenotype

1. Background

The brain is made up of two variety of tissues “Gray matter” and “White Matter”. The white Comment by Hp: The brain introduction

matter medulla lies below the Gray matter cortex containing millions of neuronal

axons(Fields, 2010). These fibres are divergent constituting 50% of volume of adult brain and

link neurons located in various functional areas of the brain(Filley, 2022; Yu, Lin, Liu, & Li,

2020). The tracts are enveloped with myelin sheet propagating fast electrical impulses.

Disarrangement of these neuronal fibres causes impairment of neurons, disturbance in

mediating nerve impulses and loss of myelin sheet hastening dysfunction(Bergstrom et al.,

1986; O’Brien et al., 1987). Brain tumours like glioblastoma are space occupying lesions Comment by Hp: Talk about Brain tumours

which displace or infiltrate the white matter fibres. These tumours traverse the neural tract

like corticospinal tract, inferior longitudinal fasciculus and anterior thalamic radiations

leading to drop-in overall survival rate(Mickevicius et al., 2015). An individual with brain Comment by Hp: Headache talk about

tumour is one of the dreaded factors of headache. The headache in brain tumour is recorded

in 31% to 71% of patients (Vazquez‐Barquero et al, 1994). The brain tumour headaches are

associated with various neurological deficits like seizures, nausea, vomiting, change in

individuality, blurring of vision and papilledema (Christiaans et al, 2002, Loghin and Levin,

2006). In the absence of intracranial pressure, the brain tumour headaches are placid and less

likely to cause associated neurological symptoms. A headache with a diversification mimics

an underlying brain tumour. The neurological deficits can be prevented by preoperative

interventions before opting for a neurosurgery procedure. Magnetic resonance imaging (MRI)

is a non-invasive technique appropriate in ruling out, handling, and forecasting prognosis of

brain tumours preventing an individual from hazardous radiation exposure. However, the

structural MRI is fails to identify the white matter fibres(Pujol, 2015).

Diffusion tensor imaging is one of the crucial modalities of MRI which conceptualize the white matter tract focusing on connectivity of the tumour with the neighbouring brain tissue(Basser & Comment by Hp: Talk about Diffusion-tensor imagig

Pierpaoli, 1998). The principle of DTI is established on anisotropic water movement along

the white matter which is unrestricted down the tracts and restricted perpendicular to the

tract. It assist in expressing fibre arrangement on a pixel by pixel ground and measure the

movement anisotropy known as functional anisotropy (FA)(Lim & Helpern, 2002; Sotak,

2002; Takahashi et al., 2002). In the present situation, preoperative DTI tractography of the

white matter tract is necessary to provide a 3D visualization of the white matter fibres to

understand the anatomical location, asymmetry and variability in relations to the brain

tumours that will assist the neurosurgeons in carrying out their procedures in crucial areas of

the brain cortex. A quantifiable data demonstrating altered diffusion figures with details of

orientation through Directionally encoded colour (DEC) maps will be taken which will guide

the surgeons with significant clinical information by tracking the position and durability of

the peritumoural fibres adjacent to the tumours. Therefore, this study will emphasize on

investigation and interpretation of fractional (FA) anisotropic changes and mean diffusivity

(MD) by tractography of white matter fibres in brain tumour patients in connection with

headache and non-headache phenotype.

2. Review of literature

A patient with a brain tumour will show specific indications or symptoms, and a new

complaint of headache is always causing concern for both the patient and the doctor. A

decision to evaluate the headache is critical because it involves a number of issues, including

time therapeutic value, clinical confidence, and limits. By ruling out any underlying

pathology, the neuroimaging of the brain tumour patient will instil confidence in clinicians

(Kernick et al, 2008). Magnetic resonance imaging (MRI) modalities play a critical role in

non-invasive techniques for detecting brain tumours linked with headache (Chiang et al,

4

2018).

Diffusion tensor imaging (DTI) is a technique that assesses the microstructural

solidarity of brain tissue. It can be utilised to examine the tissue integrity of white matter

(WM) tracts in particular(Richter, Woernle, Krayenbühl, Kollias, & Bellut, 2015). Fractional

anisotropy (FA) is a scalar (range 0–1) that describes how anisotropic the diffusion is. When

the diffusion is same in all direction it is isotropic with FA value of 0, as in cerebrospinal

fluid. Consequently, when diffusion occurs along one axis, an FA value of 1 is present. The

overall non-directional diffusion across the WM tract is measured by mean diffusivity (MD),

axonal diffusivity (AD), and radial diffusivity (RD), which is measured perpendicular to

AD(Kattem Husøy, Eikenes, Håberg, Hagen, & Stovner, 2019). Because water diffusion

parallel to fibre tracts is less restricted than diffusion perpendicular to fibre tracts, FA in

white matter is high(Pierpaoli, Jezzard, Basser, Barnett, & Di Chiro, 1996). Variations in the

FA in different parts of the brain have been linked to the intensity of depressive symptoms

(Blood et al., 2010). Furthermore, Afferent and efferent fibre abnormalities from the medial

prefrontal and orbitofrontal cortex, as well as the thalamus, are closely linked to the onset of

depression symptoms aggravating headache(Price & Drevets, 2010). In patients with

headache, the mean number of hyperintensities in extremely acute pain increased with wide

white matter hyperintensities increased considerably with growing pain intensity during the

attack(Negm, Housseini, Abdelfatah, & Asran, 2018). Previous studies showed that

decreasing the fractional anisotropy (FA) threshold could boost tracking in tumours and

oedema(Akai et al., 2005). With reference to individual's 3-dimensional brain architecture,

white matter tractography (WMT) offers a useful complementary technique for studying the

optic tract-optic radiation (OR) and the Meyer loop structure in vivo(Wu et al., 2012). WMT

offers useful neuropsychological prognostic information that might assist with patient

counselling before planning treatment(McDonald et al., 2008). Cortical and subcortical brain

regions can be impacted with headache or with a single seizure centre because of coordinated

5

neuronal firing through neural networks(Thivard et al., 2005). Hence, Evaluation of the white

matter tracts that connect these diverse locations may therefore be able to provide light on the

generalised alterations in the brain associated with headache and non-headache phenotypes in

brain tumour patients.

3. Problem statement

A brain tumour is one of the most commonly feared causes of headache, and many

individuals come with an underlying tumour (Goffaux & Fortin, 2010). Other neurological

1- https://www.academia.edu/22624836/Characterization_of_displaced_white_matter_by_brain_tumors_using_combined_DTI_and_fMRI?auto=download

2- https://www.researchgate.net/publication/50850000_An_Introduction_to_Diffusion_Tensor_Image_Analysis

Collepals.com Plagiarism Free Papers

Are you looking for custom essay writing service or even dissertation writing services? Just request for our write my paper service, and we'll match you with the best essay writer in your subject! With an exceptional team of professional academic experts in a wide range of subjects, we can guarantee you an unrivaled quality of custom-written papers.

Get ZERO PLAGIARISM, HUMAN WRITTEN ESSAYS

Why Hire Collepals.com writers to do your paper?

Quality- We are experienced and have access to ample research materials.

We write plagiarism Free Content

Confidential- We never share or sell your personal information to third parties.

Support-Chat with us today! We are always waiting to answer all your questions.