Increased folic acid intake before conception is likely to reduce the risk of which of the following birth defects?

Question 1 

Increased folic acid intake before conception is likely to reduce the risk of which of the following birth defects?

Question options:

1) congenital cataract

2) pyloric stenosis

3) clubfoot

4) open neural tube defects

Question 2 

Down syndrome is the clinical manifestation of trisomy ___.

Question options:

1) 13

2) 15

3) 18

4) 21