Reduced Bioavailability time Discussion

Reduced Bioavailability time Discussion

Reduced Bioavailability time Discussion

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Week 2 Assignment 2 Quiz 1. Question :A patient’s nutritional intake and lab work reflect hypoalbuminemia. This is critical to prescribing because: Distribution of drugs to target tissue may be affected The solubility of the drug will not match the site of absorption There will be less free drug available to generate an effect Drugs bound to albumin are readily excreted by the kidney Question 2. Drugs that have a significant first-pass effect: Must be given by the enteral (oral) route only Bypass the hepatic circulation Are rapidly metabolized by the liver and may have little if any desired action Are converted by the liver to more active and fat-soluble forms Question 3. An advantage of prescribing a sublingual medication is that the medication is: Absorbed rapidly Excreted rapidly Metabolized minimally Distributed equally Question 4. Which one of the following statements about bioavailability is true? Bioavailability issues are especially important for drugs with narrow therapeutic ranges or sustained release mechanisms. All brands of a drug have the same bioavailability. Drugs that are administered more than once a day have greater bioavailability than drugs given once daily. Combining an active drug with an inert substance does not affect bioavailability. Question 5. The route of excretion of a volatile drug will likely be: The kidneys The lungs The bile and feces The skin Question 6. The time required for the amount of drug in the body to decrease by 50% is called: Steady state Half-life Phase II metabolism Reduced bioavailability time Question 7. The elderly are at high risk of ADRs due to: Having greater muscle mass than younger adults, leading to higher volume of distribution The extensive studies that have been conducted on drug safety in this age group The blood-brain barrier being less permeable, requiring higher doses to achieve therapeutic effect Age-related decrease in renal function Question 8. Patient education regarding prescribed medication includes: Instructions written at the high school reading level Discussion of expected ADRs How to store leftover medication such as antibiotics Verbal instructions always in English Question 9. Pharmacokinetic factors that affect prescribing include: Therapeutic index Minimum effective concentration Bioavailability Ease of titration Question 10. Drugs that use CYP3A4 isoenzymes for metabolism may: Induce the metabolism of another drug Inhibit the metabolism of another drug Both A and B Neither A nor B

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