Bioavailability Case Assignment

Bioavailability Case Assignment

Bioavailability Case Assignment

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Week 2 Assignment 2 Quiz 1. Question :A patient’s nutritional intake and lab work reflect hypoalbuminemia. This is critical to prescribing because: Distribution of drugs to target tissue may be affected The solubility of the drug will not match the site of absorption There will be less free drug available to generate an effect Drugs bound to albumin are readily excreted by the kidney Question 2. Drugs that have a significant first-pass effect: Must be given by the enteral (oral) route only Bypass the hepatic circulation Are rapidly metabolized by the liver and may have little if any desired action Are converted by the liver to more active and fat-soluble forms Question 3. An advantage of prescribing a sublingual medication is that the medication is: Absorbed rapidly Excreted rapidly Metabolized minimally Distributed equally Question 4. Which one of the following statements about bioavailability is true? Bioavailability issues are especially important for drugs with narrow therapeutic ranges or sustained release mechanisms. All brands of a drug have the same bioavailability. Drugs that are administered more than once a day have greater bioavailability than drugs given once daily. Combining an active drug with an inert substance does not affect bioavailability. Question 5. The route of excretion of a volatile drug will likely be: The kidneys The lungs The bile and feces The skin

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In pharmacology, bioavailability (BA or F) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. By definition, when a medication is administered intravenously, its bioavailability is 100%.[1] However, when a medication is administered via other routes (such as orally), its bioavailability generally[TH] decreases (due to incomplete absorption and first-pass metabolism) or may vary from patient to patient. Bioavailability is one of the essential tools in pharmacokinetics, as bioavailability must be considered when calculating dosages for non-intravenous routes of administration.

For dietary supplements, herbs and other nutrients in which the route of administration is nearly always oral, bioavailability generally designates simply the quantity or fraction of the ingested dose that is absorbed.[2]

Bioavailability is defined slightly differently for drugs as opposed to dietary supplements primarily due to the method of administration and Food and Drug Administration regulations.