Discussion: Hormones causing Breast Cancer

Discussion: Hormones causing Breast Cancer

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Discussion: Hormones causing Breast Cancer

PART 3:

A 44-year-old patient presents with lump in the chest of approximately 2 cm in diameter. There is a slight dimple over the location of the lump and when the lump is manipulated it seems to be attached to the surrounding tissue. A lumpectomy is performed and the mass is sent to pathology. The pathology report comes back and the mass is confirmed to be an estrogen receptor negative, a progesterone receptor negative and a her2/neu receptor positive breast cancer.

• What are some of the risk factors for breast cancer?

• What tumor suppressor genes are associated with breast cancer?

• What tumor oncogenes are associated with breast cancer?

• Compare and contrast tumor suppressor genes from oncogenes?

Studies have also shown that a woman’s risk of breast cancer is related to theestrogen and progesterone made by her ovaries (known as endogenous estrogenand progesterone). Being exposed for a long time and/or to high levels of thesehormones has been linked to an increased risk of breast cancer

Estrogen is a female hormone made mainly in the ovaries. It’s important for sexual development and other body functions. From your first monthly period until menopause, estrogen stimulates normal breast cells. A higher lifetime exposure to estrogen may increase breast cancer risk.

Estrogen-only HRT increases the risk of breast cancer, but only when used for more than 10 years. Estrogen-only HRT also can increase the risk of ovarian cancer. The higher breast cancer risk from using HRT is the same for so-called “bioidentical” and “natural” hormones as it is for synthetic hormones.

Estrogen And Breast Cancer. The molecular form for one type of estrogen called estriol. High levels of estrogen in the body have been shown to be a risk factor forbreast cancer. High estrogen levels in the body are believed to dramaticallyincrease our risk of breast cancer.

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