The mid-term paper will consist of your findings from Bioinformatic analyses in the format of a scientific paper (Introduction, Methods, Results, Discussion, and References).For this paper you will do the following: Do a complete literature search on the Marfan syndrome disease and its related genes.This information MUST be incorporated in the paper. Search the GenBank database for a set of related entries pertaining to a human disease causes in part by a Single Nucleotide Polymorphism.The best candidates for this study should be genetic variations of the same gene or set of genes. Determine the important motifs in the DNA sequences (i.e. ORF’s) as well as composition analysis (i.e. GC content) Search the literature and suggest how these gene’s expression is controlled Suggest a method for a quick test for identifying individuals that may carry the disease alleles (i.e. RFLP) using both literature and LaserGene methods Suggest a microarray method for further studying gene expression for this disease (may expand beyond the current gene being analyzed There are also some old homework, which it may include information about the disease, you can use it in writing there research (there are some words in red color and that means it is a wrong information you need to fix it before use it).
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