Different advantages of S. cerevisiae in human genetics

I need 600 words on the different advantages of S. cerevisiae in human genetics

– e.g. Advantage as subheading (description)

600 words on the disadvantages (I have included exampples of factors you can expand on)

Vancouver referencing please

Thank you

Requirements: 600 words

Advantages 600 (no need for intro)

Present the initial advantages of the organisms that led to them becoming a model organism, i.e. what is so great about your assigned model organism compared to others (RELATING TO GENETICS)?!

● General things to consider: cost of experiments, tools available, time it takes to carry out experiments, progeny time and number, how relevant is the experimental model to the human disease being studied, are there ethical implications to consider?

Disadvantages 600

Present the disadvantages of the organism compared to the other model organisms and how technology has been used to overcome these issues.

General things to consider: cost of experiments, tools available, time it takes to carry out experiments, how relevant is the experimental model to the human disease being studied, storage of transgenic organisms, are there ethical implications?

● What are the remaining disadvantages and what technology needs to be developed to overcome these issues?

Green advantages, yellow neutral, red disadvantage

Examples of genetic applications to include:

Typical features of higher eukaryotes – nucleus, subcellular organelles

• The simplest of eukaryotes with a relatively small genome (3 x larger than E. coli)

• Can be manipulated using techniques applicable to E. coli e.g. making mutants

• Yeast mutants important for understanding many fundamental processes in eukaryotes (e.g. autophagy Week 8)

• Grows rapidly (by budding)

• 16 linear chromosomes (haploid and diploid forms)

Key discovers in yeast: 1. Cell cycle regulation 2. DNA replication 3. Recombination 4. Metabolism 5. DNA damage response Wine and beer production!