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July 13, 2023

X-linked hypophosphatemia

X-linked hypophosphatemia is an X-linked dominant disorder that is associated with rickets-like leg deformities. A mutation in gene H is associated with the dominant form of the disease. Given this information, please answer the following questions:

A. If a mother is heterozygous for X-linked hypophosphatemia (Hh) and the father does not have X-linked hypophosphatemia what are the chances their male child will have X-linked hypophosphatemia?

B. If a mother is homozygous for X-linked hypophosphatemia (HH) and the father does not have X-linked hypophosphatemia what are the chances their male child will have X-linked hypophosphatemia?

C. If a father has X-linked hypophosphatemia (H) and the mother does not have X-linked hypophosphatemia, what are the chances their male children will have X-linked hypophosphatemia?

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