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January 22, 2023

What is the relative direction of topoisomerases moving the unbroken strand? For example, after topoisomerase 1 nicks a strand in one right handed DNA strand, it can eit

What is the relative direction of topoisomerases moving the unbroken strand?
For example, after topoisomerase 1 nicks a strand in one right handed DNA strand, it can either move the unbroken strand counter clockwise (left handed) or clockwise (right handed) relative to the broken strand. To increase linking number by +1, would it move right handed or left handed?

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