An investigational medication has the following pharmacokinetic parameters: Vd = 26 L F = 0.75 Ke = 0.0753 hr1
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Get it written →An investigational medication has the following pharmacokinetic parameters: Vd = 26 L F = 0.75 Ke = 0.0753 hr1 Recommended dose = 250 mg IV Q12H Recommended monitoring = trough level (immediately before dose) at steady state A test subject started receiving the investigational medication dosed at 250 mg IV Q12H on Tuesday at 0700 (dose #1). Assuming all doses are given on schedule and steady state is achieved after 5 half-lives, when can the earliest trough level be obtained? • A. Immediately before the 3rd dose on Wednesday at 0700 • B. Immediately before the 4th dose on Wednesday at 1900 C. Immediately before the 5th dose on Thursday at 0700 • D. Immediately before the 6th dose on Thursday at 1900 • E. Immediately before the 7th dose on Friday at 0700
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