Anemia Classification

1. Type of anemia a. Folate Deficiency b. Anemia of Inflammation c. Iron Deficiency Anemia d. Vitamin B12 Deficiency e. Thalassemia

2. Classification of anemia a. Microcytic-hypochromic b. Macrocytic-normochromic c. Normocytic-normochromic

3. After identifying the type and class, describe the pathophysiology of each of the anemias.

Use the following normal CBC ranges

WBC 4500-11,000/mm³

RBC Male: 4.3-5.9 million/mm³ Female: 3.5-5.5 million/mm³

Hemoglobin Male: 13.5-17.5 g/dL Female: 12.0-16.0 g/dL

Hematocrit Male: 41%-53% Female: 36%-46%

Mean corpuscular volume 80-100 µ³

Mean corpuscular hemoglobin concentration 32-36 g/dL

Serum iron Males: 50-150 mcg/dL Females: 35-145 mcg/dL

Ferritin Males: 30-400 ng/mL Females: 13-150 ng/mL

Total iron-binding capacity 240-450 mcg/dL

Transferrin saturation Males: 20-50% Females: 15-50%

Reticulocyte count 0.5-2.17%

Vitamin B12 160-950 pg/mL

Folate 2.7-17.0 ng/mL

Scenario 1

• Hemoglobin (Hgb): 9.5 g/dL • Hematocrit (Hct): 28% • Mean Corpuscular Volume (MCV): 68 fL • Mean Corpuscular Hemoglobin Concentration (MCHC): 27 g/dL • Serum Iron: 25 mcg/dL • Ferritin: 10 ng/mL • Total Iron-Binding Capacity (TIBC): 470 mcg/dL • Transferrin Saturation: 5% • Reticulocyte Count: 1%

Scenario 2

• Hemoglobin (Hgb): 8.9 g/dL • Hematocrit (Hct): 26% • Mean Corpuscular Volume (MCV): 115 fL • Mean Corpuscular Hemoglobin Concentration (MCHC): 34 g/dL • Serum Vitamin B12: 120 pg/mL • Folate: 6 ng/mL • Reticulocyte Count: 0.3%

Scenario 3

• Hemoglobin (Hgb): 9.1 g/dL • Hematocrit (Hct): 27% • Mean Corpuscular Volume (MCV): 112 fL • Mean Corpuscular Hemoglobin Concentration (MCHC): 31 g/dL • Serum Folate: 1.8 ng/mL • Vitamin B12: 380 pg/mL • Reticulocyte Count: 1.2%

Scenario 4

• Hemoglobin (Hgb): 10.5 g/dL • Hematocrit (Hct): 32% • Mean Corpuscular Volume (MCV): 80 fL • Mean Corpuscular Hemoglobin Concentration (MCHC): 34 g/dL • Serum Iron: 30 mcg/dL • Ferritin: 500 ng/mL • Total Iron-Binding Capacity (TIBC): 220 mcg/dL • Transferrin Saturation: 12% • Reticulocyte Count: 1%

Scenario 5

• Hemoglobin (Hgb): 10.0 g/dL • Hematocrit (Hct): 30% • Mean Corpuscular Volume (MCV): 65 fL • Mean Corpuscular Hemoglobin Concentration (MCHC): 28 g/dL • Serum Iron: 80 mcg/dL • Ferritin: 150 ng/mL • Total Iron-Binding Capacity (TIBC): 300 mcg/dL • Transferrin Saturation: 27%

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