Advanced Pathophysiology Analysis
In this assignment, you will conduct A comprehensive analysis of the molecular mechanisms underlying a specific disease or condition of your choice. The purpose of this assignment is to enhance your understanding of advanced pathophysiology concepts and their application to clinical practice, as well as to explore the latest research findings and therapeutic implications related to selected diseases.
The objectives of this assignment include being able to critically analyze the molecular mechanisms underlying the development and progression of a chosen disease or condition, evaluate the role of genetic, environmental, and immunological factors in pathophysiology, and to demonstrate a comprehensive understanding of advanced pathophysiology concepts through the application of molecular mechanisms to clinical manifestations of the selected disease.
This assignment will focus on the following course student learning outcomes (CSLO):
1. Evaluate the concepts of cellular biology and altered cellular and tissue biology for their implications to disease management (EOPSLO# 1).
1. Distinguish knowledge of normal physiology and pathologic alterations across the lifespan that are expressed as diseases of organs and systems (EOPSLO# 1, 9).
1. Analyze current research findings with evidence-based guidelines for the management of selected diseases (EOPSLO# 4, 9).
Instructions: Please choose one disease or condition being learned in the course. Once the disease or condition is chosen, you are to write a three-to-five-page paper in APA format 7th edition with the following sections and level 2 headings:
Introduction
-Brief overview of the definition of pathophysiology
-Introduce the disease condition chosen
-Importance of understanding pathophysiology
Literature Review
-conduct A thorough literature review to explore the molecular pathophysiology of the chosen disease.
-Identify and analyze peer reviewed articles, research studies, and/or scholarly sources to define molecular mechanisms, genetic factors, environmental triggers, and/or immunological pathways associated with the condition.
Pathogenesis
-provide a detailed analysis of the molecular mechanisms underlying the pathogenesis and progression of the chosen disease. This may include genetic predisposition, dysregulation of immune responses, cellular signaling pathways, and tissue-specific effects.
Clinical Correlation
-correlate the identified molecular pathways with the clinical manifestations and symptoms of the chosen disease.
-Discuss how an understanding of the molecular pathophysiology can inform clinical assessment, diagnosis, and treatment decisions.
Conclusion
-Recap points discussed in paper
-Importance of understanding pathophysiology as an advanced practice nurse.
References
-Please include at least 5 references on its own page, within the last 5 years with included in-text citations.
Sickle cell anemia statistics in United States 2024
https://www.cdc.gov/sickle-cell/data/index.html
1. Sickle cell disease (SCD) affects about 100,000 people in the United States.
1. The estimated life expectancy of those with SCD in the United States is more than 20 years shorter than the average expected.
1. More than 90% of people in the United States with SCD are non-Hispanic Black or African American (Black), and an estimated 3%–9% are Hispanic or Latino.
1. SCD occurs in about 1 out of every 365 Black or African American births and about 1 out of every 16,300 Hispanic American births.
1. About 1 in 13 Black or African American babies is born with sickle cell trait (SCT, inheritance of a sickle cell gene from only one parent).
https://www.medicalnewstoday.com/articles/how-common-is-sickle-cell-anemia#prevalence
1. SCD affects approximately 100,000 people in the United States.
1. around 1 out of every 365 Black or African American babies have SCD
1. around 1 out of every 16,300 Hispanic American babies have SCD
According to the CDC, approximately 1 in 13Trusted Source Black or African American babies have SCT.
https://www.nhlbi.nih.gov/health/sickle-cell-disease
Sickle cell disease affects more than 100,000 people in the United States and 8 million people worldwide. In the United States, 9 of 10 people who have sickle cell disease are of African ancestry or identify as Black:
1. About 1 in 13 Black babies are born with sickle cell trait, meaning that they inherited a sickle cell gene from one parent.
1. About 1 in every 365 Black babies are born with sickle cell disease, meaning they inherited a sickle cell gene from each parent.
https://medlineplus.gov/sicklecelldisease.html
1. About 1 in 13 Black or African American babies are born with sickle cell trait
1. About 1 in every 365 Black or African American babies are born with sickle cell disease
In the United States, about 1 in every 365 Black or African American infants and 1 in every 16,300 Hispanic American infants in the United States are born with SCD.
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