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February 4, 2023

The patient has been taking an oral dose of drug X at a dose and dosing interval that resulted in a therapeutic steady state plasma concentration for the last several weeks. This week the level

The patient has been taking an oral dose of drug X at a dose and dosing interval that resulted in a therapeutic steady state plasma concentration for the last several weeks. This week the level of drug X in the patient’s blood dropped below therapeutic levels. Which of the following statements could explain this finding:

A. The patient has been started on a second drug that inhibits P-glycoprotein

B. The patient has been started on a second drug that inhibits CYP450 enzymes

C. The patient has been started on a second drug that competes with drug X for renal tubular secretion

D. The patient has been started on a second drug that induces CYP450 enzymes

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