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In orotic aciduria, the activities of two components of a large enzyme complex are deficient: both orotate phosphoribosyl transferase (synthesizes nucleotides) and orotod

In orotic aciduria, the activities of two components of a large enzyme complex are deficient: both orotate phosphoribosyl transferase (synthesizes nucleotides) and orotodylic acid decarboxylase (converts OMP toUMP) are inactive.
This leads to orotic acid build up and DNA and RNA will not be synthesized. Pyrimidines as uridine (uridine-riboside are used and administered to treat individuals. This leads to formation of UTP, TTP, and CTP and stops the build up of orotic acid.
Which of the following explains why orotic acid no longer builds up?
because CTP and TTP…….
A. activate carbamoyl phosphate synthetase-II (CPS-II)
B. inhibit CPS-II
C. inhibit PRPP:glutamine amidotransferase
D. inhibit CPS-III
E. inhibit enzymes of the pyrimidine degradation pathway

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