Suppose that your company has just developed a new screening test for a disease, and you are in charge of testing its validity and feasibility. Y
Suppose that your company has just developed a new screening test for a disease, and you are in charge of testing its validity and feasibility. You decide to evaluate the test on 1,000 individuals and compare the results of the new test to the gold standard. You know the prevalence of disease in your population is 30%, so 300 people actually have the disease and would test positive using the gold standard. The screening test gave a positive result for 292 individuals. 285 of these individuals actually had the disease on the basis of the gold standard determination. a. Fill in all cells of the appropriate 2×2 table. (10 pts) b. Calculate the sensitivity of the new screening test. (5 pts) c. Interpret the results of sensitivity calculation. (2 pts) d. Calculate the specificity of the new screening test. (5 pts) e. Interpret the results of specificity calculation. (2 pts) f. Calculate the positive predictive value for this new screening test. (5 pts) g. Interpret the results of the positive predictive value calculation. (2 pts) EXTRA CREDIT: What would happen to the predictive value positive if this test were administered in a population with a disease prevalence of 1% instead of 30%? (Note that the sensitivity and specificity of the test remain the same.) Would it remain the same? Increase? Decrease? (5 pts)
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