Principles of Pharmacology.

Principles of Pharmacology.

QUESTION: This question has four parts (A-D). You must complete all four parts.

You are measuring the current of voltage gated Na+ channels in neurons using the whole-cell patch clamp technique.

A. Draw the expected Na+ currents when you depolarize for 50 ms from a holding potential of -100 mV to various test potentials: -70 mV, -40 mV, O mV, +65 mV 0 and +100 mV (you may superimpose the traces or draw them separately and remember to pay attention to the timescale). 0

B. Draw the I-V curve for the Na+ channel current from Part A. What is the approximate threshold voltage for activation? What is the approximate reversal potential?

C. Imagine the Na+ channel was a mutant that was permeable to all cations. Draw the 1-V curve for this mutant channel. What is the approximate reversal potential?

D. You treat the neurons with a scorpion toxin that abolishes inactivation. Draw the expected Na+ current evoked by depolarization from – 100 mV to 0 mV of 50 ms duration. Draw the expected action potential waveform before and after you add the scorpion toxin. Explain briefly (one or 2 sentences) what is happening?

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