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October 30, 2022

The initial studies establishing maternal diethylstilbesterol (DES) intake as a cause of vaginal adenocarcinoma in female offspring were case-control studies

The initial studies establishing maternal diethylstilbesterol (DES) intake as a cause of vaginal adenocarcinoma in female offspring were case-control studies. This was probably largely because:

A couple of decades ago cohort studies hadn’t been invented.

A woman taking DES was always rare.

The disease outcome is rare.

The investigators had probably just happened to have a number of cases in their practices.

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