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August 24, 2020

Formulating medications for extended release

Students must answer only one of the following questions.

Question 1. Formulating medications for extended release can increase the duration of action of many drugs. Describe and discuss how the coating of oral solid dosage forms can achieve extended release.

Question 2. Describe and discuss excipients used in transdermal formulations and the mechanisms by which they improve absorption.

Question 3. Discuss recent advances using cyclodextrins and other macromolecular hosts to improve solubility of drugs and excipients.

Question 4. Discuss the application of microencapsulation techniques in pharmaceutical formulation.

Question 5. The nose offers a convenient access route to a large mucosal surface which is well suited for drug and vaccine delivery. Unfortunately, factors such as nasal anatomy, physiology and aerodynamics severely complicate intra-nasal drug and vaccine delivery. Describe and discuss strategies for improving nasal absorption of either drugs or vaccines.

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