Sally is a 50-year-old female who has been a jogger for several years. She has recently been diagnosed with osteoarthritis. She has been taking ibuprofen for 3 months but

Sally is a 50-year-old female who has been a jogger for several years. She has recently been diagnosed with osteoarthritis. She has been taking ibuprofen for 3 months but states that “it does not help” and hurts her stomach. The health care provider prescribes celecoxib (Celebrex) 100 mg orally twice a day.

1. What is the first-line therapy for osteoarthritis and the mechanism of action?
2. Sally expresses concern about all the recent news about heart problems and celecoxib (Celebrex). What information should be included in a teaching plan to help her understand about taking celecoxib and the benefits and risks?
3. Ibuprofen and celecoxib are both nonsteroidal anti-inflammatory drugs. Explain how they are similar and different.

Submission Instructions:

APA 7 edition is a must.

NO WEBSITES ALLOWED FOR REFERENCE OR CITATION. 500 words at least. References and citation must be only from journal articles or books published from 2017 up to now. Must employ at least 3 references entries which will be cited at the end of the paragraph. INCLUDE DOI, PAGE NUMBERS. etc PLAGIARISM NEED TO BE LESS THAN 10%.